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pH- and temperature-sensitive, injectable, biodegradable block copolymer hydrogels as carriers for paclitaxel
- Authors
- Shim, WS[Shim, Woo Sun]; Kim, JH[Kim, Jong-Ho]; Kim, K[Kim, Kwangmeyung]; Kim, YS[Kim, Yoo-Shin]; Park, RW[Park, Rang-Woon]; Kim, IS[Kim, In-San]; Kwon, IC[Kwon, Ick Chan]; Lee, DS[Lee, Doo Sung]
- Issue Date
- 22-Feb-2007
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- pH/T-sensitive block copolymer hydrogel; injectable hydrogel; paclitaxel; in vivo anti-tumor effect; TUNEL assay
- Citation
- INTERNATIONAL JOURNAL OF PHARMACEUTICS, v.331, no.1, pp.11 - 18
- Indexed
- SCIE
SCOPUS
- Journal Title
- INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Volume
- 331
- Number
- 1
- Start Page
- 11
- End Page
- 18
- ISSN
- 0378-5173
- Abstract
- Paclitaxel (PTX) was loaded into synthetic pH/T-sensitive block copolymer (OSM-PCLA-PEG-PCLA-OSM) solution with various concentrations. The phase diagram of PTX-loaded block copolymer solution shifted to lower temperature region compared to net block copolymer because of the salting-out effect of PTX. Release profiles of PTX showed sustained manner regardless of loading amount of PTX. To evaluate anti-tumor effect of PTX-loaded block copolymer, solutions were injected subcutaneously to tumor-bearing mice and TUNEL assay examined. PTX-loaded block copolymer hydrogel for in vivo use showed good anti-tumor effect for 2 weeks and induced strong apoptosis in tumor tissue. Therefore, we conclude OSM-PCLA-PEG-PCLA-OSM block copolymer as an effective injectable carrier of PTX (c) 2006 Elsevier B.V. All rights reserved.
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