Pharmacokinetics of baicalein, baicalin and wogonin after oral administration of a standardized extract of Scutellaria baicalensis, PF-2405 in rats
- Authors
- Kim, YH[Kim, Young Hoon]; Jeong, DW[Jeong, Dong Won]; Kim, YC[Kim, Yoon-Cheol]; Sohn, DH[Sohn, Dong Hwan]; Park, ES[Park, Eun-Seok]; Lee, HS[Lee, Hye Suk]
- Issue Date
- Feb-2007
- Publisher
- PHARMACEUTICAL SOCIETY KOREA
- Keywords
- standardized extract of Scutellaria baicalensis (PF-2405); pharmacokinetics; baicalein; baicalin; wogonin; rats
- Citation
- ARCHIVES OF PHARMACAL RESEARCH, v.30, no.2, pp.260 - 265
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- ARCHIVES OF PHARMACAL RESEARCH
- Volume
- 30
- Number
- 2
- Start Page
- 260
- End Page
- 265
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/85032
- DOI
- 10.1007/BF02977703
- ISSN
- 0253-6269
- Abstract
- The pharmacokinetics of active components such as baicalein, wogonin and oroxylin A were evaluated after oral administration of a purified extract of Scutellaria baicalensis GEORGI (PF-2405) containing the high contents of baicalein, wogonin and oroxylin A to rats. Following oral administration of PF-2405 at 10, 20 and 40 mg/kg dose (equivalent to 4.5, 9.0 and 18 mg/kg baicalein), a major constituent baicalein and its active metabolite baicalin showed dose-linear pharmacokinetics; as evidenced by unaltered dose-normalized AUC, dose-normalized Cm, Ae(0-30h) and Gl(30h) values. Following oral administration of PF-2405 at three doses (equivalent to 0.4, 0.8 and 1.6 mg/kg wogonin), dose-normalized Cm and dose-normalized AUC were comparable between the 20 and 40 mg/kg PF2405 doses, but plasma concentrations of wogonin at 10 mg/kg of PF-2405 were not measurable as they were below limit of quantitation (LOQ; 18 pmol/mL). Following oral administration of PF-2405 at the three doses (equivalent to 1.5, 3.0 and 6.0 mg/kg oroxylin A), the concentrations of oroxylin A in plasma, urine and gastrointestine samples were below the assay LOQ (18 pmol/mL). Significant differences in AUCs, Ae(0-30h) and Gl(30h) values for baicalein and baicalin were observed after oral administration of pure baicalein (18 mg/kg) and PF-2405 (40 mg/kg). The increases in AUCs of baicalein and baicalin after oral administration of PF-2405 may have been due to the significant decrease in Gl(30h) values for baicalein.
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