Detailed Information

Cited 55 time in webofscience Cited 59 time in scopus
Metadata Downloads

Cryptotanshinone from Salvia miltiorrhiza BUNGE has an inhibitory effect on TNF-alpha-induced matrix metalloproteinase-9 production and HASMC migration via down-regulated NF-kappa B and AP-1

Authors
Suh, SJ[Suh, Seok-Jong]Jin, UH[Jin, Un-Ho]Choi, HJ[Choi, Hee-Jung]Chang, HW[Chang, Hyen Wook]Son, JK[Son, Jong-Keun]Lee, SH[Lee, Seung Ho]Jeon, SJ[Jeon, Su-Jin]Son, KH[Son, Kun-Ho]Chang, YC[Chang, Young-Chae]Lee, YC[Lee, Young-Choon]Kim, CH[Kim, Cheorl-Ho]
Issue Date
15-Dec-2006
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Keywords
cryptotanshinone; Salviae miltiorrahizae (Salvia miltiorrhiza Bunge); matrix metalloproteinase-9; human aortic smooth muscle cells; TNF-alpha; migration
Citation
BIOCHEMICAL PHARMACOLOGY, v.72, no.12, pp.1680 - 1689
Indexed
SCIE
SCOPUS
Journal Title
BIOCHEMICAL PHARMACOLOGY
Volume
72
Number
12
Start Page
1680
End Page
1689
URI
https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/86360
DOI
10.1016/j.bcp.2006.08.013
ISSN
0006-2952
Abstract
Matrix metalloproteinases (MMP-9 and MMP-2) production and smooth muscle cell (SMC) migration may play key roles in the phathogenesis of neointima formation and atherosclerosis. Especially inducible MMP-9 expression was directly involved in the cancer cell invasion and SMC migration through vascular wall. In this study, we reveal that cryptotanshinone (CT) purified from Salvia miltiorrhiza BUNGE had an inhibitory effect on MMP-9 production and migration of human aortic smooth muscle cells treated with TNF-alpha in a dose-dependent manner. The down regulation of transcription of MMP-9 mRNA was evidenced by RT-PCR and MMP-9 promoter assay using luciferase reporter gene. Eletrophoretic mobility shift assay showed NF-kappa B and AP-1 nuclear translocations were suppressed. In addition, Western blot analysis indicated that extracellular signal regulated kinase 1 and 2, p38 and JNK MAP kinase signaling pathways were inhibited. From the results, it is suggested that CT has anti- atherosclerosis and anti-neointimal formation activity. (c) 2006 Elsevier Inc. All rights reserved.
Files in This Item
There are no files associated with this item.
Appears in
Collections
Science > Department of Biological Science > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher KIM, CHEORL HO photo

KIM, CHEORL HO
Science (Biological Sciences)
Read more

Altmetrics

Total Views & Downloads

BROWSE