F-18-FDG PET/CT of thymic epithelial tumors: Usefulness for distinguishing and staging tumor subgroups
- Authors
- Sung, YM[Sung, Yon Mi]; Lee, KS[Lee, Kyung Soo]; Kim, BT[Kim, Byung-Tae]; Choi, JY[Choi, Joon Young]; Shim, YM[Shim, Young Mog]; Yi, CA[Yi, Chin A.]
- Issue Date
- Oct-2006
- Publisher
- SOC NUCLEAR MEDICINE INC
- Citation
- JOURNAL OF NUCLEAR MEDICINE, v.47, no.10, pp.1628 - 1634
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF NUCLEAR MEDICINE
- Volume
- 47
- Number
- 10
- Start Page
- 1628
- End Page
- 1634
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/86701
- ISSN
- 0161-5505
- Abstract
- The purpose of our study was to assess the usefulness of integrated PET/CT using F-18-FDG for distinguishing thymic epithelial tumors according to the World Health Organization (WHO) classification. Methods: Thirty-three patients (age range, 34-68 y; mean age, 54.6 y) with thymic epithelial tumors, who underwent both integrated PET/CT and enhanced CT, were included. The clinicopathologic stages, maximum standardized uptake values (SUVs), and uptake patterns of tumors on integrated PET/CT images, and various enhanced CT findings, are described according to the simplified (low-risk [types A, AB, and B1] and high-risk [types B2 and B3] thymomas and thymic carcinomas) subgroups of the WHO classification. Discriminant analysis was performed to determine the relative capabilities of integrated PET/CT and enhanced CT findings to differentiate tumor subgroups. Results: Tumors included 8 low-risk thymomas, 9 high-risk thymomas, and 16 thymic carcinomas. The maximum SUVs of high-risk thymomas (P < 0.001) and low-risk thymomas (P < 0.001) were found to be significantly lower than those oDf thymic carcinomas. Homogeneous F-18-FDG uptake within tumors was more frequently seen in thymic carcinomas than in high-risk thymomas (P = 0.027) or low-risk thymomas (P = 0.001). The uptake pattern (homogeneous vs. heterogeneous) on integrated PET/CT images and the presence of mediastinal fat invasion on enhanced CT images were found to be useful for differentiating tumor subgroups. In addition, integrated PET/CT helped detect lymph node metastases, which were not identified on enhanced CT in 2 patients. Conclusion: Integrated PET/CT was found to be useful for differentiating subgroups of thymic epithelial tumors and for staging the extent of the disease.
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- Appears in
Collections - Medicine > Department of Medicine > 1. Journal Articles
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