Protoberberine alkaloids and their reversal activity of P-gp expressed multidrug resistance (MDR) from the rhizome of Coptis japonica Makino
- Authors
- Min, YD[Min, Yong Deuk]; Yang, MC[Yang, Min Cheol]; Lee, KH[Lee, Kyu Ha]; Kim, KR[Kim, Kyung Ran]; Choi, SU[Choi, Sang Un]; Lee, KR[Lee, Kang Ro]
- Issue Date
- Sep-2006
- Publisher
- PHARMACEUTICAL SOCIETY KOREA
- Citation
- ARCHIVES OF PHARMACAL RESEARCH, v.29, no.9, pp.757 - 761
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- ARCHIVES OF PHARMACAL RESEARCH
- Volume
- 29
- Number
- 9
- Start Page
- 757
- End Page
- 761
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/86867
- DOI
- 10.1007/BF02974076
- ISSN
- 0253-6269
- Abstract
- Six protoberberine alkaloids were isolated from the chloroform layer of the rhizome of Coptis japonica Makino (Ranunculaceae). The structures of the isolated compounds were determined to be 6-([1,3]dioxolo[4,5-g]isoquinoline-5-carbonyl)-2,3-dimethoxy-benzoic acid methyl ester (1), oxyberberine (2), 8-oxo-epiberberine (3), 8-oxocoptisine (4), berberine (5) and palmatine (6) by physicochemical and spectroscopic methods. The compound 3 (8-oxo-epiberberine) was first isolated from natural sources. The compounds were tested for cytotoxicity against five tumor cell lines in vitro by SRB method, and also tested for the MDR reversal activities. Compound 4 was of significant P-gp MDR inhibition activity with ED50 value 0.018 mu g/mL in MES-SA/DX5 cell and 0.0005 mu g/mL in HCT15 cell, respectively.
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