Aporphine alkaloids and their reversal activity of multidrug resistance (MDR) from the stems and rhizomes of Sinomenium acutum
- Authors
- Min, YD[Min, Yong Deuk]; Choi, SU[Choi, Sang Un]; Lee, KR[Lee, Kang Ro]
- Issue Date
- Aug-2006
- Publisher
- PHARMACEUTICAL SOCIETY KOREA
- Citation
- ARCHIVES OF PHARMACAL RESEARCH, v.29, no.8, pp.627 - 632
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- ARCHIVES OF PHARMACAL RESEARCH
- Volume
- 29
- Number
- 8
- Start Page
- 627
- End Page
- 632
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/86979
- DOI
- 10.1007/BF02968246
- ISSN
- 0253-6269
- Abstract
- Chromatographic separation of the MeOH extract from the stems and rhizomes of Sinomemium acutum led to the isolation of nine alkaloids and a lignan. Their structures were determined to be dauriporphine (1), bianfugecine (2), dauriporphinoline (3), menisporphine (4), (-) syringaresinol (5), N-feruloyltyramine (6), acutumine (7), dauricumine (8), sinomenine (9), and magnoflorine (10) by spectroscopic means. These compounds were examined for their P-gp mediated MDR reversal activity in human cancer cells. Compound 1 showed the most potent P-gp MDR inhibition activity with an ED50 value 0.03 mu g/mL and 0.00010 mu g/mL in the MESSA/DX5 and HCT15 cells, respectively.
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Collections - Pharmacy > Department of Pharmacy > 1. Journal Articles
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