Prognostic significance of vascular endothelial growth factor expression and microvessel density in esophageal squamous cell carcinoma: Comparison with positron emission tomography
- Authors
- Choi, JY[Choi, Joon Young]; Jang, KT[Jang, Kee-Taek]; Shim, YM[Shim, Young Mog]; Kim, K[Kim, Kwhanmien]; Ahn, G[Ahn, Geunghwan]; Lee, KH[Lee, Kyung-Han]; Choi, Y[Choi, Yong]; Choe, YS[Choe, Yearn Seong]; Kim, BT[Kim, Byung-Tae]
- Issue Date
- Aug-2006
- Publisher
- SPRINGER
- Citation
- ANNALS OF SURGICAL ONCOLOGY, v.13, no.8, pp.1054 - 1062
- Indexed
- SCIE
SCOPUS
- Journal Title
- ANNALS OF SURGICAL ONCOLOGY
- Volume
- 13
- Number
- 8
- Start Page
- 1054
- End Page
- 1062
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/86984
- DOI
- 10.1245/ASO.2006.08.012
- ISSN
- 1068-9265
- Abstract
- Background: This study investigated whether the expression of vascular endothelial growth factor (VEGF) in a primary tumor and the intratumoral microvessel density (MVD) were independent prognostic factors in patients with an esophageal squamous cell carcinoma (SCC) in comparison with positron emission tomography (PET) by using F-18-fluorodeoxyglucose (FDG) and stage. Methods: Fifty-one patients with a newly diagnosed esophageal SCC who underwent preoperative FDG-PET and esophagectomy with intent to cure were enrolled in this study. The VEGF expression level, the intratumoral MVD, and the Ki-67 labeling index were evaluated by using immunohistochemical staining. Only significant variables in the univariate survival analysis were examined by multivariate survival analysis with the Cox proportional hazards model. Result: Cancer-related deaths occurred in 17 of 51 patients during the follow-up. Univariate survival analysis showed that the pathologic stage, pNM, maximum standardized uptake value of the primary tumor, tumor length on PET, number of PET-positive lymph nodes, PET stage, Ki-67 labeling index, intratumoral MVD, and the presence of VEGF expression were significant prognostic predictors for the overall survival. Multivariate analysis revealed that the pathologic stage, number of PET-positive nodes (0, 1, 2, or >= 3), intratumoral MVD (cutoff, 60/mm(2)), and presence of VEGF expression were independent significant prognostic predictors for overall survival. Conclusion: In addition to the pathologic stage, the intratumoral MVD, the presence of VEGF expression, and the number of FDG-PET-positive nodes were independent prognostic predictors in patients with an esophageal SCC undergoing curative surgery.
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Collections - Medicine > Department of Medicine > 1. Journal Articles
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