Promoter methylation of helicase-like transcription factor is associated with the early stages of gastric cancer with family history
- Authors
- Kim, JJ[Kim, JJ]; Chung, SW[Chung, SW]; Kim, JH[Kim, JH]; Kim, JW[Kim, JW]; Oh, JS[Oh, JS]; Kim, S[Kim, S]; Song, SY[Song, SY]; Park, J[Park, J]; Kim, DH[Kim, DH]
- Issue Date
- Apr-2006
- Publisher
- OXFORD UNIV PRESS
- Keywords
- HLTF; methylation; gastric cancer; family history; early stage
- Citation
- ANNALS OF ONCOLOGY, v.17, no.4, pp.657 - 662
- Indexed
- SCIE
SCOPUS
- Journal Title
- ANNALS OF ONCOLOGY
- Volume
- 17
- Number
- 4
- Start Page
- 657
- End Page
- 662
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/87494
- DOI
- 10.1093/annonc/mdl018
- ISSN
- 0923-7534
- Abstract
- Background: To investigate the clinicopathological significance of promoter methylation of the helicase-like transcription factor (HLTF) in primary gastric cancer. Patients and methods: Two-hundred fifty six patients participated in this study. Methylation status of HLTF gene was evaluated in fresh-frozen tissues by the methylation-specific polymerase chain reaction. All statistical analyses were two-sided, with a 5% type I error rate. Results: Aberrant methylation of HLTF was found in 98 (38%) of 256 gastric cancer patients. HLTF methylation was significantly associated with a family history in the early stages of gastric cancer, regardless of histologic types. In intestinal-type cases, HLTF methylation occurred in 15 (56%) of 27 patients with family histories, and in 26 (31%) of 85 patients without family histories (P = 0.02). In diffuse-type cases, patients with family histories were also found to exhibit a higher prevalence of HLTF methylation than those without family histories (61% vs. 34%; P = 0.009). HLTF methylation in both of the histologic types occurred in about 70-90% of the early stage cases in which the patient had a family history and in 15-30% of cases in which the patient did not have a family history. In our multivariate logistic regression analysis, the stage 1-2 cases with family histories were determined to carry a higher risk of HLTF methylation than did the stage 3-4 cases without family histories in both the intestinal-type (OR = 6.01, 95% CI = 1.20-30.01, P = 0.02) and the diffuse-type cancers (OR = 8.25, 95% CI = 1.67-40.86, P = 0.009). Conclusions: These results suggest that HLTF methylation may play a crucial role in the early stages of gastric carcinogenesis in patients with family histories and may be a valuable susceptible marker for the risk of gastric cancer in individuals with family histories.
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Collections - Medicine > Department of Medicine > 1. Journal Articles
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