Anti-Inflammatory and Photoaging-Protective Effects of Olea europaea through Inhibition of AP-1 and NF-kappa B Pathways
- Authors
- Song, Chaoran; Jeong, Deok; Hong, Yo Han; Li, Wan Yi; Lee, Sang Woo; Hossain, Mohammad Amjad; Taamalli, Amani; Kim, Ji Hye; Kim, Jong-Hoon; Cho, Jae Youl
- Issue Date
- 2020
- Publisher
- WORLD SCIENTIFIC PUBL CO PTE LTD
- Keywords
- Olea europaea; Antiphotoaging Effect; Anti-Inflammatory Effect; AP-1; NF-kappa B
- Citation
- AMERICAN JOURNAL OF CHINESE MEDICINE, v.48, no.8, pp 1895 - 1913
- Pages
- 19
- Indexed
- SCIE
SCOPUS
- Journal Title
- AMERICAN JOURNAL OF CHINESE MEDICINE
- Volume
- 48
- Number
- 8
- Start Page
- 1895
- End Page
- 1913
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/89770
- DOI
- 10.1142/S0192415X20500950
- ISSN
- 0192-415X
1793-6853
- Abstract
- Olea europaea is a beneficial edible plant with a number of biological activities like anti-inflammatory, anti-oxidant, antithrombic, antihyperglycemic, and anti-ischemic activities. The mechanisms behind the antiphotoaging and anti-inflammatory effects of Olea europaea are not fully understood. To investigate how an ethanol extract of Olea europaea (Oe-EE) exerts these effects, we explored its activities in human keratinocytes and dermal fibroblasts. We assessed the anti-oxidant effects of Oe-EE via 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2 '-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS) assays and measured the expression levels of matrix metalloproteinases (MMPs), cyclooxygenase-2, interleukin (IL)-6, tumor necrosis factor (TNF)-alpha, and moisturizing factors. Antiphotoaging and anti-inflammatory mechanisms of Oe-EE were explored by assessing signaling molecule activation via immunoblotting. Oe-EE treatment decreased the mRNA expression level of MMPs, cyclooxygenase-2, IL-6, and TNF-alpha and restored type I collagen, filaggrin, and sirtuin 1 expression in UVB-irradiated cells. Furthermore, Oe-EE inhibited the activities of several activator protein 1 regulatory enzymes, including extracellular signal-regulated kinase (ERK), p38, and c-Jun N-terminal kinase (JNK), and inhibited nuclear factor (NF)-kappa B pathway signaling proteins. Therefore, our results indicate that Oe-EE has photoaging-protective and anti-inflammatory effects.
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- Appears in
Collections - Biotechnology and Bioengineering > Integrative Biotechnology > 1. Journal Articles
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