Site-Selective C-H Alkylation of Diazine N-Oxides Enabled by Phosphonium Ylides
- Authors
- Ghosh, P[Ghosh, Prithwish]; Kwon, NY[Kwon, Na Yeon]; Han, S[Han, Sangil]; Kim, S[Kim, Saegun]; Han, SH[Han, Sang Hoon]; Mishra, NK[Mishra, Neeraj Kumar]; Jung, YH[Jung, Young Hoon]; Chung, SJ[Chung, Sang J.]; Kim, IS[Kim, In Su]
- Issue Date
- 16-Aug-2019
- Publisher
- AMER CHEMICAL SOC
- Citation
- ORGANIC LETTERS, v.21, no.16, pp.6488 - 6493
- Indexed
- SCIE
SCOPUS
- Journal Title
- ORGANIC LETTERS
- Volume
- 21
- Number
- 16
- Start Page
- 6488
- End Page
- 6493
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/9036
- DOI
- 10.1021/acs.orglett.9b02365
- ISSN
- 1523-7060
- Abstract
- The synthesis of alkylated diazine derivatives is important for their practical utilization as pharmaceuticals and for other purposes. Herein, we describe the metal-free site-selective C-H alkylation of diazine N-oxides using phosphonium ylides that affords a variety of alkylated diazine derivatives with broad functional group tolerance. The utility of this method is showcased by the late-stage functionalization of a commercially available drug such as varenicline. Notably, the sequential C-H alkylation of pyrazine N-oxides for the total synthesis of a pyrazine-containing natural product, paenibacillin A, highlights the importance of this method.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - Pharmacy > Department of Pharmacy > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/9036)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.