Effects of the re-esterified triglyceride (rTG) form of omega-3 supplements on dry eye following cataract surgery
- Authors
- Park, J[Park, Jongyeop]; Yoo, YS[Yoo, Young-Sik]; Shin, E[Shin, Eunhae]; Han, G[Han, Gyule]; Shin, K[Shin, Kyungyoon]; Lim, DH[Lim, Dong Hui]; Chung, TY[Chung, Tae-Young]
- Issue Date
- Nov-2021
- Publisher
- BMJ PUBLISHING GROUP
- Keywords
- Ocular surface; Clinical Trial; Treatment Medical
- Citation
- BRITISH JOURNAL OF OPHTHALMOLOGY, v.105, no.11, pp.1504 - 1509
- Indexed
- SCIE
SCOPUS
- Journal Title
- BRITISH JOURNAL OF OPHTHALMOLOGY
- Volume
- 105
- Number
- 11
- Start Page
- 1504
- End Page
- 1509
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/90722
- DOI
- 10.1136/bjophthalmol-2020-317164
- ISSN
- 0007-1161
- Abstract
- Background/Aims To evaluate the clinical outcomes of the systemic re-esterified triglyceride (rTG) form of omega-3 fatty acids in patients with dry eye symptoms after cataract surgery. Methods This prospective comparative cohort study comprised 66 patients complaining of new-onset non-specific typical dry eye 1 month after uncomplicated cataract surgery. Subjects were randomly allocated into control and omega-3 groups based on administration of the systemic rTG form of omega-3 fatty acids for 2 months, in addition to use of artificial teardrop. Ocular surface parameters (Schirmer's test, tear break-up time, corneal staining score and matrix metalloproteinase-9 (MMP-9)) and subjective questionnaire results (Ocular Surface Disease Index (OSDI)) and Dry Eye Questionnaire [DEQ]) for dry eye were evaluated before and after omega-3 supplementation. Results Two months after omega-3 supplementation, the Oxford score was lower in the omega-3 group than in the control group. There was an improvement of subjective symptom scores of OSDI and DEQ in the omega-3 group (both p<0.05). The ratio of increasing MMP-9 level in the omega-3 group was lower than that in the control group (p=0.027). Conclusion The rTG form of omega-3 supplementation might be related to reduction of ocular surface inflammation rather than secretion of tears, and it might be effective for non-specific typical dry eye after uncomplicated cataract surgery.
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Collections - Medicine > Department of Medicine > 1. Journal Articles
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