Synthesis of spirosuccinimides via annulative cyclization between N-aryl indazolols and maleimides under rhodium(iii) catalysis
- Authors
- Kang, JY[Kang, Ju Young]; An, W[An, Won]; Kim, S[Kim, Suho]; Kwon, NY[Kwon, Na Yeon]; Jeong, T[Jeong, Taejoo]; Ghosh, P[Ghosh, Prithwish]; Kim, HS[Kim, Hyung Sik]; Mishra, NK[Mishra, Neeraj Kumar]; Kim, IS[Kim, In Su]
- Issue Date
- Oct-2021
- Publisher
- ROYAL SOC CHEMISTRY
- Citation
- CHEMICAL COMMUNICATIONS, v.57, no.83, pp.10947 - 10950
- Indexed
- SCIE
SCOPUS
- Journal Title
- CHEMICAL COMMUNICATIONS
- Volume
- 57
- Number
- 83
- Start Page
- 10947
- End Page
- 10950
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/90841
- DOI
- 10.1039/d1cc04599g
- ISSN
- 1359-7345
- Abstract
- The rhodium(iii)-catalyzed spiroannulation reaction between N-aryl indazol-3-ols and maleimides is described herein. The developed method is showcased by the construction of spirosuccinimides using bioactive molecule-linked and chemical probe-linked maleimides. Combined mechanistic investigations including the determination of an isolable rhodacycle complex aided the elucidation of a plausible reaction mechanism.
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Collections - Pharmacy > Department of Pharmacy > 1. Journal Articles
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