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EBP1 regulates Suv39H1 stability via the ubiquitin-proteasome system in neural development
- Authors
- Kim, B.-S.[Kim, B.-S.]; Ko, H.R.[Ko, H.R.]; Hwang, I.[Hwang, I.]; Cho, S.-W.[Cho, S.-W.]; Ahn, J.-Y.[Ahn, J.-Y.]
- Issue Date
- 31-Aug-2021
- Publisher
- The Biochemical Society of the Republic of Korea
- Keywords
- ErbB3-binding protein 1; MDM2; Suppressor of variegation 3-9 homolog 1; Ubiquitin-proteasome system
- Citation
- BMB Reports, v.54, no.8, pp.413 - 418
- Indexed
- SCIE
SCOPUS
KCI
OTHER
- Journal Title
- BMB Reports
- Volume
- 54
- Number
- 8
- Start Page
- 413
- End Page
- 418
- ISSN
- 1976-6696
- Abstract
- ErbB3-binding protein 1 (EBP1) is a multifunctional protein associated with neural development. Loss of Ebp1 leads to upregulation of the gene silencing unit suppressor of variegation 3-9 homolog 1 (Suv39H1)/DNA (cytosine 5)-methyltransferase (DNMT1). EBP1 directly binds to the promoter region of DNMT1, repressing DNA methylation, and hence, promoting neural development. In the current study, we showed that EBP1 suppresses histone methyltransferase activity of Suv39H1 by promoting ubiquitin-proteasome system (UPS)-dependent degradation of Suv39H1. In addition, we showed that EBP1 directly interacts with Suv39H1, and this interaction is required for recruiting the E3 ligase MDM2 for Suv39H1 degradation. Thus, our findings suggest that EBP1 regulates UPS-dependent degradation of Suv39H1 to govern proper heterochromatin assembly during neural development. © 2021 by the The Korean Society for Biochemistry and Molecular Biology. All Rights Reserved.
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