Long-acting nanoparticulate DNase-1 for effective suppression of SARS-CoV-2-mediated neutrophil activities and cytokine stormopen access
- Authors
- Lee, YY[Lee, Yun Young]; Park, HH[Park, Hee Ho]; Park, W[Park, Wooram]; Kim, H[Kim, Hyelim]; Jang, JG[Jang, Jong Geol]; Hong, KS[Hong, Kyung Soo]; Lee, JY[Lee, Jae-Young]; Seo, HS[Seo, Hee Seung]; Na, DH[Na, Dong Hee]; Kim, TH[Kim, Tae-Hyung]; Choy, YB[Choy, Young Bin]; Ahn, JH[Ahn, June Hong]; Lee, W[Lee, Wonhwa]; Park, CG[Park, Chun Gwon]
- Issue Date
- Jan-2021
- Publisher
- ELSEVIER SCI LTD
- Keywords
- COVID-19; Sepsis; DNase; Nanoparticles; NETosis
- Citation
- BIOMATERIALS, v.267
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOMATERIALS
- Volume
- 267
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/92422
- DOI
- 10.1016/j.biomaterials.2020.120389
- ISSN
- 0142-9612
- Abstract
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new strain of coronavirus not previously identified in humans. Globally, the number of confirmed cases and mortality rates of coronavirus disease 2019 (COVID-19) have risen dramatically. Currently, there are no FDA-approved antiviral drugs and there is an urgency to develop treatment strategies that can effectively suppress SARS-CoV-2-mediated cytokine storms, acute respiratory distress syndrome (ARDS), and sepsis. As symptoms progress in patients with SARS-CoV-2 sepsis, elevated amounts of cell-free DNA (cfDNA) are produced, which in turn induce multiple organ failure in these patients. Furthermore, plasma levels of DNase-1 are markedly reduced in SARS-CoV-2 sepsis patients. In this study, we generated recombinant DNase-1-coated polydopamine-poly(ethylene glycol) nanoparticulates (named long-acting DNase-1), and hypothesized that exogenous administration of long-acting DNase-1 may suppress SARS-CoV-2-mediated neutrophil activities and the cytokine storm. Our findings suggest that exogenously administered long-acting nanoparticulate DNase-1 can effectively reduce cfDNA levels and neutrophil activities and may be used as a potential therapeutic intervention for life-threatening SARS-CoV-2-mediated illnesses.
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Collections - SKKU Institute for Convergence > Biomedical Engineering > 1. Journal Articles
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