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Direct Integration of Phthalazinone and Succinimide Scaffolds via Rh(III)-Catalyzed C-H Functionalization
- Authors
- Cho, YS[Cho, Yong Sun]; Kim, HD[Kim, Hak Do]; Kim, E[Kim, Euntaek]; Han, SH[Han, Sang Hoon]; Han, SB[Han, Soo Bong]; Mishra, NK[Mishra, Neeraj Kumarj]; Jung, YH[Jung, Young Hoon]; Jeong, T[Jeong, Taejoo]; Kim, IS[Kim, In Su]
- Issue Date
- Jan-2021
- Publisher
- WILEY-V C H VERLAG GMBH
- Keywords
- C-H functionalization; maleimides; phthalazinones; succinimides; rhodium
- Citation
- ASIAN JOURNAL OF ORGANIC CHEMISTRY, v.10, no.1, pp.202 - 209
- Indexed
- SCIE
SCOPUS
- Journal Title
- ASIAN JOURNAL OF ORGANIC CHEMISTRY
- Volume
- 10
- Number
- 1
- Start Page
- 202
- End Page
- 209
- ISSN
- 2193-5807
- Abstract
- The development of new methods for the direct synthesis of bioactive molecules is a pivotal topic in organic and medicinal chemistry. Herein, we describe the rhodium(III)-catalyzed C-H functionalization ofN-aryl phthalazinones with maleimides. The complete site-selectivity and broad functional group tolerance are observed. Notably, this protocol allows the direct integration of phthalazinones and succinimides, which are vital motifs found in bioactive natural products and pharmaceuticals.
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Collections - Pharmacy > Department of Pharmacy > 1. Journal Articles
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