D* from diffusion MRI reveals a correspondence between ventricular cerebrospinal fluid volume and flow in the ischemic rodent model
- Authors
- Jang, M.[Jang, M.]; Han, S.[Han, S.]; Cho, H.[Cho, H.]
- Issue Date
- Apr-2022
- Publisher
- SAGE Publications Ltd
- Keywords
- cerebrospinal fluid flow; Cerebrospinal fluid volume; diffusion MRI; ischemic stroke; subacute stage
- Citation
- Journal of Cerebral Blood Flow and Metabolism, v.42, no.4, pp.572 - 583
- Indexed
- SCIE
SCOPUS
- Journal Title
- Journal of Cerebral Blood Flow and Metabolism
- Volume
- 42
- Number
- 4
- Start Page
- 572
- End Page
- 583
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/92686
- DOI
- 10.1177/0271678X211060741
- ISSN
- 0271-678X
- Abstract
- Quantitative measurement of cerebrospinal fluid (CSF) flow and volume and longitudinal monitoring of CSF dynamics provide insights into the compensatory characteristics of post-stroke CSF. In this study, we compared the MRI pseudo-diffusion index (D*) of live and sacrificed rat brains to confirm the effect of ventricular CSF flow on diffusion signals. We observed the relationship between the CSF peak velocities and D* through Monte Carlo (MC) simulations to further understand the source of D* contrast. We also determined the dominant CSF flow using D* in three directions. Finally, we investigated the dynamic evolutions of ventricular CSF flow and volume in a stroke rat model (n = 8) from preoperative to up to 45 days after surgery and determined the correlation between ventricular CSF volume and flow. MC simulations showed a strong positive correlation between the CSF peak velocity and D* (r = 0.99). The dominant CSF flow variations in the 3D ventricle could be measured using the maximum D* map. A longitudinal positive correlation between ventricular CSF volume and D* was observed in the lateral (r = 0.74) and ventral-third (r = 0.81) ventricles, respectively. The directional D* measurements provide quantitative CSF volume and flow information, which would provide useful insights into ischemic stroke with diffusion MRI. © The Author(s) 2021.
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