Phenotypic Differences of CD103(+) Tissue-Resident Memory T Cells Associated with Various Cancers
- Authors
- Park, HS[Park, Hye Seon]; Jeon, Y[Jeon, Yeonjin]; Lee, H[Lee, Hyun]; Lee, H[Lee, Heejae]; Kim, YA[Kim, Young-Ae]; Park, IA[Park, In Ah]; Bang, WS[Bang, Won Seon]; Lee, M[Lee, Miseon]; Cho, YJ[Cho, Young Jin]; Kim, J[Kim, Jihyeong]; Gong, G[Gong, Gyungyub]; Lee, HJ[Lee, Hee Jin]
- Issue Date
- 2023
- Publisher
- KARGER
- Keywords
- Human cancer; Single cell; CD103; Tissue-resident memory T cell
- Citation
- PATHOBIOLOGY, v.89, no.2, pp.116 - 126
- Indexed
- SCIE
SCOPUS
- Journal Title
- PATHOBIOLOGY
- Volume
- 89
- Number
- 2
- Start Page
- 116
- End Page
- 126
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/93182
- DOI
- 10.1159/000518972
- ISSN
- 1015-2008
- Abstract
- Background/Aims: The presence and clinical importance of tissue-resident memory T (T-RM) cells have been recently described in association with various cancer types. However, the frequency and the traditional naive-effector-memory phenotypic characteristics of T-RM cells are largely unknown. Methods: We analyzed single-cell populations of colorectal cancer (CC, n = 18), stomach cancer (SC, n = 13), renal cell carcinoma (RCC, n = 19), and breast cancer (BC, n = 16) by dissociation of tumor tissue with collagenase/hyaluronidase. We investigated populations of naive, effector, and memory T and T-RM cells by flow cytometry. Results: Among CD8(-) cells, CC was associated with a significantly higher proportion of CD103(+) T cells than other tumor types (p < 0.001). Among CD8(+) cells, CC and SC were associated with higher CD103(+) T-cell proportions than RCC and BC (p < 0.001). Significantly more CD8(+) than CD8(-) cells expressed CD103 (p < 0.001). In association with SC, RCC, and BC, CD8(+) T cells had a similar T-cell phenotype composition pattern: fewer effector T cells and more memory-type T cells among CD103(+) cells compared with CD103(-) cells (p < 0.05). Tumors with higher proportion of CD103(+) cells had no specific clinicopathologic characteristics than those with lower proportion of CD103(+) cells. Conclusion: T-RM cell abundance and phenotypes varied among CC, SC, RCC, and BC. Further studies regarding the functional differences of T-RM associated with various tumors are warranted. </p>
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Collections - Medicine > Department of Medicine > 1. Journal Articles
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