Free-water diffusion tensor imaging detects occult periependymal abnormality in the AQP4-IgG-seropositive neuromyelitis optica spectrum disorder
- Authors
- Kim, M.[Kim, M.]; Choi, K.S.[Choi, K.S.]; Hyun, R.C.[Hyun, R.C.]; Hwang, I.[Hwang, I.]; Yun, T.J.[Yun, T.J.]; Kim, S.M.[Kim, S.M.]; Kim, J.-H.[Kim, J.-H.]
- Issue Date
- 11-Jan-2022
- Publisher
- Nature Research
- Citation
- Scientific Reports, v.12, no.1
- Indexed
- SCIE
SCOPUS
- Journal Title
- Scientific Reports
- Volume
- 12
- Number
- 1
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/95419
- DOI
- 10.1038/s41598-021-04490-3
- ISSN
- 2045-2322
- Abstract
- To compare free-water corrected diffusion tensor imaging (DTI) measures in the normal-appearing periependymal area between AQP4-IgG-seropositive NMOSD and multiple sclerosis (MS) to investigate occult pathophysiology. This prospective study included 44 patients (mean age, 39.52 ± 11.90 years; 14 men) with AQP4-IgG-seropositive NMOSD (n = 20) and MS (n = 24) who underwent DTI between April 2014 and April 2020. Based on free-water corrected DTI measures obtained from normal-appearing periependymal voxels of (1) lateral ventricles and (2) the 3rd and 4th ventricles as dependent variables, MANCOVA was conducted to compare the two groups, using clinical variables as covariates. A significant difference was found between AQP4-IgG-seropositive NMOSD and MS in the 3rd and 4th periependymal voxels (λ = 0.462, P = 0.001). Fractional anisotropy, axial diffusivity was significantly decreased and radial diffusivity was increased in AQP4-IgG-seropositive NMOSD in post-hoc analysis, compared with MS (F = 27.616, P < 0.001, F = 7.336, P = 0.011, and F = 5.800, P = 0.022, respectively). Free-water corrected DTI measures differ in the periependymal area surrounding the diencephalon and brain stem/cerebellum between MS and NMOSD, which may suggest occult white matter injury in areas with distribution of AQP-4 in NMOSD. © 2022, The Author(s).
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Collections - Medicine > Department of Medicine > 1. Journal Articles
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