Anti-Apoptotic and Anti-Inflammatory Activities of Edible Fresh Water Algae Prasiola japonica in UVB-Irradiated Skin Keratinocytes
- Authors
- Choi E.[Choi E.]; Yi Y.-S.[Yi Y.-S.]; Lee J.[Lee J.]; Park S.H.[Park S.H.]; Kim S.[Kim S.]; Hossain M.A.[Hossain M.A.]; Jang S.[Jang S.]; Choi Y.I.[Choi Y.I.]; Park K.J.[Park K.J.]; Kim D.S.[Kim D.S.]; Kim J.-H.[Kim J.-H.]; Cho J.Y.[Cho J.Y.]
- Issue Date
- 2019
- Publisher
- World Scientific Publishing Co. Pte Ltd
- Keywords
- Anti-Apoptotic Effect; Anti-Inflammatory Effect; Anti-Oxidant; Green Algae; Keratinocytes; Prasiola japonica
- Citation
- American Journal of Chinese Medicine, v.47, no.8, pp.1853 - 1868
- Indexed
- SCIE
SCOPUS
- Journal Title
- American Journal of Chinese Medicine
- Volume
- 47
- Number
- 8
- Start Page
- 1853
- End Page
- 1868
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/95878
- DOI
- 10.1142/S0192415X19500940
- ISSN
- 0192-415X
- Abstract
- Skin is the outer tissue layer and is a barrier protecting the body from various external stresses. The fresh water green edible algae Prasiola japonica has antiviral, antimicrobial, and anti-inflammatory properties; however, few studies of its effects on skin-protection have been reported. In this study, Prasiola japonica ethanol extract (Pj-EE) was prepared, and its skin-protective properties were investigated in skin keratinocytes. Pj-EE inhibited ROS production in UVB-irradiated HaCaT cells without cytotoxicity. Pj-EE also suppressed the apoptotic death of UVB-irradiated HaCaT cells by decreasing the generation of apoptotic bodies and the proteolytic activation of apoptosis caspase-3, -8, and -9. Moreover, Pj-EE downregulated the mRNA expression of the inflammatory gene cyclooxygenase-2 (COX-2), the pro-inflammatory cytokine genes interleukin (IL)-1β, IL-8, IL-6, tumor necrosis factor (TNF)-α, and interferon (IFN)-γ, and the tissue remodeling genes matrix metalloproteinase (MMP)-1, -2, -3, and -9. The Pj-EE-induced anti-inflammatory effect was mediated by suppressing the activation of nuclear factor-kappa B (NF-κB) signaling pathway in the UVB-irradiated HaCaT cells. Taken together, these results suggest that Pj-EE exerts skin-protective effects through anti-oxidant, anti-apoptotic, and anti-inflammatory activities in skin keratinocytes. © 2019 World Scientific Publishing Company.
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- Appears in
Collections - Biotechnology and Bioengineering > Integrative Biotechnology > 1. Journal Articles
- Research & Business Foundation > Research & Business Foundation > 1. Journal Articles
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