Dynamic and subtype-specific interactions between tumour burden and prognosis in breast canceropen access
- Authors
- Lee, SB[Lee, S. B.]; Kim, HK[Kim, H. -K.]; Choi, Y[Choi, Y.]; Ju, YW[Ju, Y. W.]; Lee, HB[Lee, H. -B.]; Han, W[Han, W.]; Noh, DY[Noh, D. -Y.]; Son, BH[Son, B. H.]; Ahn, SH[Ahn, S. H.]; Kim, KS[Kim, K. S.]; Nam, SJ[Nam, S. J.]; Kim, EK[Kim, E. -K.]; Park, HY[Park, H. Y.]; Park, WC[Park, W. -C.]; Lee, JW[Lee, J. W.]; Moon, HG[Moon, H. -G.]
- Issue Date
- 22-Sep-2020
- Publisher
- NATURE RESEARCH
- Citation
- SCIENTIFIC REPORTS, v.10, no.1
- Indexed
- SCIE
SCOPUS
- Journal Title
- SCIENTIFIC REPORTS
- Volume
- 10
- Number
- 1
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/96486
- DOI
- 10.1038/s41598-020-72033-3
- ISSN
- 2045-2322
- Abstract
- We investigated the relationship between the prognostic importance of anatomic tumour burden and subtypes of breast cancer using data from the Korean Breast Cancer Registry Database. In HR+/HER2+ and HR-/HER2-tumours, an increase in T stage profoundly increased the hazard of death, while the presence of lymph node metastasis was more important in HR+/HER2+ and HR-/HER2+ tumours among 131,178 patients with stage I-III breast cancer. The patterns of increasing mortality risk and tumour growth (per centimetre) and metastatic nodes (per node) were examined in 67,038 patients with a tumour diameter <= 7 cm and<8 metastatic nodes. HR+/HER2- and HR-/HER2- tumours showed a persistent increase in mortality risk with an increase in tumour diameter, while the effect was modest in HER2+ tumours. Conversely, an increased number of metastatic nodes was accompanied by a persistently increased risk in HR-/HER2+ tumours, while the effect was minimal for HR-/HER2- tumours with>3 or 4 nodes. The interactions between the prognostic significance of anatomic tumour burden and subtypes were significant. The prognostic relevance of the anatomic tumour burden was non-linear and highly dependent on the subtypes of breast cancer.
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Collections - Medicine > Department of Medicine > 1. Journal Articles
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