Down-regulation of TRPV6 Is Associated With Adverse Prognosis in Hepatocellular Carcinoma Treated With Curative Resection
- Authors
- Koh, H.H.[Koh, H.H.]; Choi, S.[Choi, S.]; Park, C.-K.[Park, C.-K.]; Ha, S.Y.[Ha, S.Y.]
- Issue Date
- Mar-2022
- Publisher
- International Institute of Anticancer Research
- Keywords
- Biomarkers; Hepatocellular carcinoma; Prognosis; Recurrence; TRPV6
- Citation
- Cancer Genomics and Proteomics, v.19, no.2, pp.259 - 269
- Indexed
- SCIE
SCOPUS
- Journal Title
- Cancer Genomics and Proteomics
- Volume
- 19
- Number
- 2
- Start Page
- 259
- End Page
- 269
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/96612
- DOI
- 10.21873/cgp.20318
- ISSN
- 1109-6535
- Abstract
- Background/Aim: Transient receptor potential vanilloid 6 (TRPV6), an endothelial Ca2+-selective entry channel, is expressed in various cancer types, and a selective TRPV6 inhibitor is currently being investigated in a clinical trial. However, TRPV6 expression in hepatocellular carcinoma (HCC) has not been reported. Materials and Methods: We evaluated TRPV6 expression in 219 cases of HCC and analyzed its association with clinicopathological parameters and prognostic significance. TRPV6 mRNA expression was compared between HCC and non-tumor liver tissues using various public datasets, and its prognostic effect was examined in The Cancer Genome Atlas (TCGA) cohort. Results: Low TRPV6 expression was found in 37.4% of patients, which was significantly associated with adverse histologic features, and patients with low TRPV6 expression had shorter recurrence-free and disease-free survival. TRPV6 mRNA expression was consistently lower in HCC compared to non-tumor liver samples in public datasets, at the whole tissue level as well as single-cell level. Patients with low TRPV6 expression in the TCGA cohort had shorter progression-free survival. Conclusion: TRPV6 expression is down-regulated in HCCs and associated with a poor prognosis. TRPV6 may be a prognostic biomarker in HCC. © 2022 International Institute of Anticancer Research. All rights reserved.
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Collections - Medicine > Department of Medicine > 1. Journal Articles
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