Muscle fat quantification using magnetic resonance imaging: case-control study of Charcot-Marie-Tooth disease patients and volunteersopen access
- Authors
- Kim, HS[Kim, Hyun Su]; Yoon, YC[Yoon, Young Cheol]; Choi, BO[Choi, Byung-Ok]; Jin, W[Jin, Wook]; Cha, JG[Cha, Jang Gyu]
- Issue Date
- Jun-2019
- Publisher
- WILEY
- Keywords
- Magnetic resonance imaging; Multiple gradient echo Dixon; Muscle fat quantification; Charcot-Marie-Tooth disease
- Citation
- JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE, v.10, no.3, pp.574 - 585
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
- Volume
- 10
- Number
- 3
- Start Page
- 574
- End Page
- 585
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/9688
- DOI
- 10.1002/jcsm.12415
- ISSN
- 2190-5991
- Abstract
- Background This study aimed to evaluate the potential value of 3D multiple gradient echo Dixon-based magnetic resonance imaging (MRI) sequence as a tool for thigh intramuscular fat quantification in Charcot-Marie-Tooth disease (CMT) patients. Methods A prospective comparison study comprising 18 CMT patients and 18 age/sex-matched volunteers was performed. MRI including 3D multiple gradient echo Dixon-based imaging was performed for each subject. Region of interest analyses were performed at the upper and lower third of both thighs. The two-sample t-test or Wilcoxon rank sum test was used for intergroup comparison of the mean muscle fat fraction. Intraclass correlation coefficients were used to evaluate the interobserver agreement and test-retest reproducibility. Semiquantitive analysis using the Goutallier classification (Grades 0-4) was performed on T1-weighted images in upper thigh muscles. For Goutallier Grade 0 muscles, comparison of the mean intramuscular fat fraction between volunteers and CMT patients was performed. Results The interobserver agreements were excellent for all measurements (intraclass correlation coefficients > 0.8). Mean muscle fat fractions were significantly higher in all the measured muscles of CMT patients (P < 0.05) except in the adductor magnus in the upper thigh (P = 0.109). Goutallier Grade 0 muscles of the CMT patients showed a significantly higher mean fat fraction compared with that of the volunteers (P < 0.05). Conclusions 3D multiple gradient echo Dixon-based MRI is a reproducible and sensitive technique which can reveal a significant difference in the fat fraction of thigh muscle, including comparison between Goutallier Grade 0 muscles, between CMT patients and volunteers.
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- Appears in
Collections - Medicine > Department of Medicine > 1. Journal Articles
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