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Relationship between Resistance to Ethambutol and Rifampin and Clinical Outcomes in Mycobacterium avium Complex Pulmonary Disease
- Issue Date
- 19-Apr-2022
- Publisher
- AMER SOC MICROBIOLOGY
- Keywords
- Mycobacterium avium complex; ethambutol; rifampin; MIC; outcome
- Citation
- ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, v.66, no.4
- Indexed
- SCIE
SCOPUS
- Journal Title
- ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Volume
- 66
- Number
- 4
- ISSN
- 0066-4804
1098-6596
- Abstract
- We evaluated the associations between the in vitro activities of ethambutol and rifampin and clinical outcomes of Mycobacterium avium complex (MAC) pulmonary disease (PD). Among 158 patients with MAC-PD, there was no relationship between high MICs for ethambutol and/or rifampin and treatment failure for MAC-PD. Ethambutol and rifampin resistance was common among MAC isolates (rates of 87% and 59%, respectively), but mutations in embB, rpoB, and rpoC were rare, with detection in only 4% of the drug-resistant MAC isolates.
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