Temporal patterns of chronic disease incidence after breast cancer: a nationwide population-based cohort studyopen access
- Authors
- Kang, D.[Kang, D.]; Kang, M.[Kang, M.]; Hong, Y.S.[Hong, Y.S.]; Park, J.[Park, J.]; Lee, J.[Lee, J.]; Seo, H.J.[Seo, H.J.]; Kim, D.W.[Kim, D.W.]; Ahn, J.S.[Ahn, J.S.]; Park, Y.H.[Park, Y.H.]; Lee, S.K.[Lee, S.K.]; Shin, D.W.[Shin, D.W.]; Guallar, E.[Guallar, E.]; Cho, J.[Cho, J.]
- Issue Date
- 31-Mar-2022
- Publisher
- Nature Research
- Citation
- Scientific Reports, v.12, no.1
- Indexed
- SCIE
SCOPUS
- Journal Title
- Scientific Reports
- Volume
- 12
- Number
- 1
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/99032
- DOI
- 10.1038/s41598-022-09542-w
- ISSN
- 2045-2322
- Abstract
- We conducted a retrospective cohort study to evaluate the temporal pattern of incidence of chronic conditions after developing breast cancer using a population-based national registry. We selected 84,969 women with newly diagnosed breast cancer between 2002 and 2016 and a 1:10 sample of age-matched non-breast cancer controls (N = 1,057,674). The main study exposure was incident breast cancer, considered as a time-varying exposure. The outcomes were incident cases of leukemia, endometrial cancer, myeloma, cardiomyopathy, osteoporosis, end stage renal disease (ESRD), pulmonary fibrosis, hypothyroidism, type 2 diabetes, hypertension and hyperlipidemia. The development of breast cancer was associated with a significantly increased risk of all outcomes analyzed except for ESRD and hypertension. The fully-adjusted risks of leukemia (HR 3.09; 95% CI 2.11–4.51), cardiomyopathy (HR 2.65; 95% CI 1.90–3.68), endometrial cancer (HR 3.53; 95% CI 2.76–4.53), hypothyroidism (HR 1.29; 95% CI 1.19–1.40), pulmonary fibrosis (HR 1.84; 95% CI 1.12–3.02), and hyperlipidemia (HR 1.24; 95% CI 1.20–1.28) remained significantly elevated after more than 5 years since diagnosis. Optimal care for breast cancer survivors requires close collaboration between oncologists and allied health care professionals to identify and manage the long-term morbidity and mortality associated with these chronic conditions. © 2022, The Author(s).
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Collections - Samsung Advanced Institute for Health Sciences and Technology, SKKU > Samsung Advanced Institute for Health Sciences and Technology, SKKU > 1. Journal Articles
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