Gold Nanorod-Assembled PEGylated Graphene-Oxide Nanocomposites for Photothermal Cancer Therapy
DC Field | Value | Language |
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dc.contributor.author | Dembereldorj, Uuriintuya | - |
dc.contributor.author | Choi, Seon Young | - |
dc.contributor.author | Ganbold, Erdene-Ochir | - |
dc.contributor.author | Song, Nam Woong | - |
dc.contributor.author | Kim, Doseok | - |
dc.contributor.author | Choo, Jaebum | - |
dc.contributor.author | Lee, So Yeong | - |
dc.contributor.author | Kim, Sehun | - |
dc.contributor.author | Joo, Sang-Woo | - |
dc.date.available | 2018-05-09T11:08:59Z | - |
dc.date.created | 2018-04-17 | - |
dc.date.issued | 2014-05 | - |
dc.identifier.issn | 0031-8655 | - |
dc.identifier.uri | http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/10060 | - |
dc.description.abstract | Gold nanorod-attached PEGylated graphene-oxide (AuNR-PEG-GO) nanocomposites were tested for a photothermal platform both in vitro and in vivo. Cytotoxicity of AuNR was reduced after encapsulation with PEG-GO along with the removal of cetyltrimethylammonium bromide (CTAB) from AuNR by HCl treatment. Cellular internalization of the CTAB-eliminated AuNR-PEG-GO nanocomposites was examined using dark-field microscopy (DFM), confocal Raman microscopy and transmission electron microscopy (TEM). To determine the photothermal effect of the AuNR-PEG-GO nanocomposites, A431 epidermoid carcinoma cells were irradiated with Xe-lamp light (60Wcm(-2)) for 5min after treatment with the AuNR-PEG-GO nanocomposites for 24h. Cell viability significantly decreased by ~40% when the AuNR-PEG-GO-encapsulated nanocomposites were irradiated with light as compared with the cells treated with only the AuNR-PEG-GO nanocomposites without any illumination. In vivo tumor experiments also indicated that HCl-treated AuNR-PEG-GO nanocomposites might efficiently reduce tumor volumes via photothermal processes. Our graphene and AuNR nanocomposites will be useful for an effective photothermal therapy. | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.relation.isPartOf | PHOTOCHEMISTRY AND PHOTOBIOLOGY | - |
dc.subject | NEAR-INFRARED ABSORBENCY | - |
dc.subject | IN-VIVO | - |
dc.subject | NANOPARTICLES | - |
dc.subject | DELIVERY | - |
dc.subject | DRUGS | - |
dc.subject | MICE | - |
dc.title | Gold Nanorod-Assembled PEGylated Graphene-Oxide Nanocomposites for Photothermal Cancer Therapy | - |
dc.type | Article | - |
dc.identifier.doi | 10.1111/php.12212 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | PHOTOCHEMISTRY AND PHOTOBIOLOGY, v.90, no.3, pp.659 - 666 | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000335261300021 | - |
dc.identifier.scopusid | 2-s2.0-84899945925 | - |
dc.citation.endPage | 666 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 659 | - |
dc.citation.title | PHOTOCHEMISTRY AND PHOTOBIOLOGY | - |
dc.citation.volume | 90 | - |
dc.contributor.affiliatedAuthor | Joo, Sang-Woo | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | NEAR-INFRARED ABSORBENCY | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | DRUGS | - |
dc.subject.keywordPlus | MICE | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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