The Chronicity of Tonsillitis Is Significantly Correlated with an Increase in an LTi Cell Portion
- Authors
- Chang, Jung Hyun; Kim, Soochan; Koo, Jihye; Lane, Peter J. L.; Yoon, Sun Och; Park, Ah Young; Kim, Kyung-Su; Kim, Mi-Yeon
- Issue Date
- Feb-2014
- Publisher
- SPRINGER/PLENUM PUBLISHERS
- Keywords
- lymphoid tissue inducer; CD4 T cell; tonsillitis; OX40L; IL-22
- Citation
- INFLAMMATION, v.37, no.1, pp.132 - 141
- Journal Title
- INFLAMMATION
- Volume
- 37
- Number
- 1
- Start Page
- 132
- End Page
- 141
- URI
- http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/10124
- DOI
- 10.1007/s10753-013-9721-0
- ISSN
- 0360-3997
- Abstract
- The current study explored the relationship between lymphoid tissue inducer (LTi) cells and patients' clinical and immunological status. LTi cells are critical for lymphoid tissue development and maintenance of CD4 T cell-dependent immune responses. The percentage of CD117(+)CD3(-)CD56(-)CD127(+) ROR gamma(+) LTi cells isolated from human tonsils was determined and correlated with changes in other immune subsets and clinical factors. We found that the portion of LTi and CD4 T cells was significantly increased in chronic tonsillitis compared to non-inflamed tonsils. Additionally, the expression of OX40 by memory CD4 T cells and OX40 ligand (OX40L) and interleukin (IL)-22 by LTi cells was higher in chronically inflamed tonsils. The treatment for tonsillitis with ibuprofen did not alter LTi cell viability and the expression of OX40L and IL-22. These results demonstrate that during chronic inflammation, LTi cells are increased and express higher levels of OX40L and IL-22, and this is correlated with an increase in memory CD4 T cells.
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- Appears in
Collections - College of Natural Sciences > School of Systems and Biomedical Science > 1. Journal Articles
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