Prognostic Factors for Patients with Bone-Only Metastasis in Breast Cancer
- Authors
- Ahn, Sung Gwe; Lee, Hak Min; Cho, Sang-Hoon; Lee, Seung Ah; Hwang, Seung Hyun; Jeong, Joon; Lee, Hy-De
- Issue Date
- 1-Sep-2013
- Publisher
- YONSEI UNIV COLLEGE MEDICINE
- Keywords
- Breast neoplasm; bone metastses; bisphosphonate
- Citation
- YONSEI MEDICAL JOURNAL, v.54, no.5, pp.1168 - 1177
- Journal Title
- YONSEI MEDICAL JOURNAL
- Volume
- 54
- Number
- 5
- Start Page
- 1168
- End Page
- 1177
- URI
- http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/11174
- DOI
- 10.3349/ymj.2013.54.5.1168
- ISSN
- 0513-5796
- Abstract
- Purpose: Bone is the most frequent site of metastasis among breast cancer patients. We investigated prognostic factors affecting survival following bone-only metastasis in breast cancer patients. Materials and Methods: The medical records of breast cancer patients who were treated and followed at Gangnam Severance Hospital retrospectively reviewed to identify patients with bone-only metastasis. Results: The median time from the diagnosis of bone-only metastasis to the last follow-up or death was 55.2 [95% confidence interval (CI), 38.6-71.9] months. The Kaplan-Meier overall survival estimate at 10 years for all patients was 34.9%. In the multivariate Cox regression model, bisphosphonate treatment [hazard ratio=0.18;.95% CI, 0.07-0.43], estrogen receptor positivity (hazard ratio=0.51; 95% CI, 0.28-0.94), and solitary bone metastasis (hazard ratio=0.32; 95% CI, 0.14-0.72) were significantly associated with longer overall survival in the bone-only recurrence group. Among the treatment modalities, only bisphosphonate treatment was identified as a significant prognostic factor. Conclusion: Identifying the factors influencing breast cancer mortality after bone-only metastasis will help clarify the clinical course and improve the treatment outcome for patients with breast cancer and bone-only metastasis. Bisphosphonates, as a significant prognostic factor, warrant further investigation.
- Files in This Item
-
Go to Link
- Appears in
Collections - College of Natural Sciences > Department of Statistics and Actuarial Science > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/11174)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.