Effects of Polymers on the Cocrystallization of Adefovir Dipivoxil and Suberic Acid
- Authors
- Jung, Sungyup; Kim, Il Won
- Issue Date
- Sep-2013
- Publisher
- POLYMER SOC KOREA
- Keywords
- cocrystallization; adefovir dipivoxil; polymeric additives; growth from solutions
- Citation
- POLYMER-KOREA, v.37, no.5, pp.663 - 668
- Journal Title
- POLYMER-KOREA
- Volume
- 37
- Number
- 5
- Start Page
- 663
- End Page
- 668
- URI
- http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/11185
- DOI
- 10.7317/pk.2013.37.5.663
- ISSN
- 0379-153X
- Abstract
- The effects of polymers on the cocrystallization of adefovir dipivoxil (AD) and suberic acid (SUB) were investigated. The polymeric additives in the present study were poly(ethylene glycol) (PEG) and poly(acrylic acid) (PAA). When the polymers were added to the solution of AD and SUB, their effects were limited to the morphology and crystallinity of the AD/SUB cocrystal, which could be also achieved without polymeric additives by the excess amount of SUB in the solution or through the solvent-assisted grinding. When the polymers were mixed with AD before adding SUB in the solution, PEG was dramatically more effective at the same amount with possible alteration of the cocrystal structure. Also, PAA completely inhibited the formation of crystals. The present study demonstrated that the effects of polymers on the cocrystallization could be tuned by simply modifying the mixing strategy.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Engineering > Department of Chemical Engineering > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/11185)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.