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Leukocyte-Mimicking Stem Cell Delivery via in Situ Coating of Cells with a Bioactive Hyperbranched Polyglycerol
- Authors
- 정재현; JOHN SCHMIDT; RICHIE KOHMAN; ANDREW ZILL; ROSS DEVOLDER; CARTNEY SMITH; MEI-HSUI LAI; ARTEM SHKUMATOV; LAWRNCE SCHOOK; STEVEN ZIMMERMAN; HYUNJOON KONG
- Issue Date
- Jun-2013
- Publisher
- AMER CHEMICAL SOC
- Citation
- JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, v.135, no.24, pp.8770 - 8773
- Journal Title
- JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Volume
- 135
- Number
- 24
- Start Page
- 8770
- End Page
- 8773
- ISSN
- 0002-7863
- Abstract
- Since stem cells emerged as a new generation of medicine, there are increasing efforts to deliver stem cells to a target tissue via intravascular injection. However, the therapeutic stem cells lack the capacity to detect and adhere to the target tissue. Therefore, this study presents synthesis of a bioactive hyperbranched polyglycerol (HPG) that can noninvasively associate with stem cells and further guide them to target sites, such as inflamed endothelium. The overall process is analogous to the way in which leukocytes are mobilized to the injured endothelium.
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Related Researcher
- Jeong, Jae Hyun
- College of Engineering (Department of Chemical)