Increased Lymphocyte Infiltration in Rheumatoid Arthritis Is Correlated with an Increase in LTi-like Cells in Synovial Fluid
DC Field | Value | Language |
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dc.contributor.author | Jihye Koo | - |
dc.contributor.author | 김수찬 | - |
dc.contributor.author | Woong Jae Jung | - |
dc.contributor.author | Ye Eun Lee | - |
dc.contributor.author | 송관규 | - |
dc.contributor.author | 김경수 | - |
dc.contributor.author | 김미연 | - |
dc.date.available | 2018-05-10T04:03:53Z | - |
dc.date.created | 2018-04-17 | - |
dc.date.issued | 2013-12 | - |
dc.identifier.issn | 1598-2629 | - |
dc.identifier.uri | http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/12049 | - |
dc.description.abstract | In this study, we compared the immune cell populations in rheumatoid arthritis (RA) synovial fluid, which shows lymphoid tissue-like structure, with those in tonsils, which are normal secondary lymphoid tissues. Firstly, we found that CD4.CD11b+ macrophages were the major population in RA synovial fluid and that B cells were the major population in tonsils. In addition, synovial fluid from patients with osteoarthritis, which is a degenerative joint disease, contained CD4+CD11b+ monocytes as the major immune cell population. Secondly, we categorized three groups based on the proportion of macrophages found in RA synovial fluid: (1) the macrophage-high group, which contained more than 80% macrophages; (2) the macrophage-intermediate group, which contained between 40% and 80% macrophages; and (3) the macrophage-low group, which contained less than 40% macrophages. In the macrophage-low group, more lymphoid tissue inducer (LTi)-like cells were detected, and the expression of OX40L and TRANCE in these cells was higher than that in the other groups. In addition, in this group, the suppressive function of regulatory T cells was downregulated. Finally, CXCL13 expression was higher in RA synovial fluid than in tonsils, but CCL21 expression was comparable in synovial fluid from all groups and in tonsils. These data demonstrate that increased lymphocyte infiltration in RA synovial fluid is correlated with an increase in LTi-like cells and the elevation of the chemokine expression. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | 대한면역학회 | - |
dc.relation.isPartOf | Immune Network | - |
dc.subject | Lymphoid tissue inducer | - |
dc.subject | Rheumatoid arthritis | - |
dc.subject | Tonsil | - |
dc.title | Increased Lymphocyte Infiltration in Rheumatoid Arthritis Is Correlated with an Increase in LTi-like Cells in Synovial Fluid | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | Immune Network, v.13, no.6, pp.240 - 248 | - |
dc.identifier.kciid | ART001989490 | - |
dc.description.journalClass | 2 | - |
dc.citation.endPage | 248 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 240 | - |
dc.citation.title | Immune Network | - |
dc.citation.volume | 13 | - |
dc.contributor.affiliatedAuthor | 김미연 | - |
dc.identifier.url | https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART001989490 | - |
dc.description.isOpenAccess | N | - |
dc.subject.keywordAuthor | Lymphoid tissue inducer | - |
dc.subject.keywordAuthor | Rheumatoid arthritis | - |
dc.subject.keywordAuthor | Tonsil | - |
dc.description.journalRegisteredClass | kci | - |
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