Fatty acid composition of beef is associated with exonic nucleotide variants of the gene encoding FASN
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Oh, Dongyep | - |
dc.contributor.author | Lee, Yoonseok | - |
dc.contributor.author | La, Boomi | - |
dc.contributor.author | Yeo, Jungsou | - |
dc.contributor.author | Chung, Euiryong | - |
dc.contributor.author | Kim, Younyoung | - |
dc.contributor.author | Lee, Chaeyoung | - |
dc.date.available | 2018-05-10T05:21:10Z | - |
dc.date.created | 2018-04-17 | - |
dc.date.issued | 2012-04 | - |
dc.identifier.issn | 0301-4851 | - |
dc.identifier.uri | http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/12460 | - |
dc.description.abstract | Genetic associations of fatty acid composition with exonic single nucleotide polymorphisms (SNPs) in the gene encoding fatty acid synthase (FASN) were examined using 513 Korean cattle. All five individual SNPs of g.12870 T > C, g.13126 T > C, g.15532 C > A, g.16907 T > C and g.17924 G > A were associated with a variety of fatty acid compositions and further with marbling score (P < 0.05). Their genotypes of CC, TT, AA, TT, and GG were associated with increased monounsaturated fatty acids and with decreased saturated fatty acids (P < 0.05). The genotypes at all the SNPs also increased marbling score (P < 0.05). Further genetic associations with fatty acid composition suggested that homozygous genotype with the haplotype of ATG at g.15532, g.16907, and g.17924 in a linkage disequilibrium block increased monounsaturated fatty acids and marbling score (P < 0.05). We concluded that the five exonic SNPs of g.12870, g.13126, g.15532, g.16907, and g.17924 in the FASN gene could change fatty acid contents. Their genotypes of CC, TT, AA, TT, and GG and haplotype of ATG at g.15532, g.16907, and g.17924 were recommended for genetic improvement of beef quality. | - |
dc.publisher | SPRINGER | - |
dc.relation.isPartOf | MOLECULAR BIOLOGY REPORTS | - |
dc.subject | DNA POLYMORPHISMS | - |
dc.subject | KOREAN CATTLE | - |
dc.subject | SYNTHASE | - |
dc.title | Fatty acid composition of beef is associated with exonic nucleotide variants of the gene encoding FASN | - |
dc.type | Article | - |
dc.identifier.doi | 10.1007/s11033-011-1190-7 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | MOLECULAR BIOLOGY REPORTS, v.39, no.4, pp.4083 - 4090 | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000301108500082 | - |
dc.identifier.scopusid | 2-s2.0-84862980934 | - |
dc.citation.endPage | 4090 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 4083 | - |
dc.citation.title | MOLECULAR BIOLOGY REPORTS | - |
dc.citation.volume | 39 | - |
dc.contributor.affiliatedAuthor | Lee, Chaeyoung | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Beef flavor | - |
dc.subject.keywordAuthor | Fatty acid composition | - |
dc.subject.keywordAuthor | Genetic association | - |
dc.subject.keywordAuthor | Unsaturated fatty acid | - |
dc.subject.keywordPlus | DNA POLYMORPHISMS | - |
dc.subject.keywordPlus | KOREAN CATTLE | - |
dc.subject.keywordPlus | SYNTHASE | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
Soongsil University Library 369 Sangdo-Ro, Dongjak-Gu, Seoul, Korea (06978)02-820-0733
COPYRIGHT ⓒ SOONGSIL UNIVERSITY, ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.