Association of glycosylated hemoglobin with the gene encoding CDKAL1 in the Korean Association Resource (KARE) study
- Authors
- Ryu, Jihye; Lee, Chaeyoung
- Issue Date
- Apr-2012
- Publisher
- WILEY-BLACKWELL
- Keywords
- GWAS; glycosylated hemoglobin; CDKAL1; diabetes
- Citation
- HUMAN MUTATION, v.33, no.4, pp.655 - 659
- Journal Title
- HUMAN MUTATION
- Volume
- 33
- Number
- 4
- Start Page
- 655
- End Page
- 659
- URI
- http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/12467
- DOI
- 10.1002/humu.22040
- ISSN
- 1059-7794
- Abstract
- Genome-wide associations with glycosylated hemoglobin, which reflects the long-term glycemia, were examined using two independent cohorts of the Korea Association Resource (KARE) consortium. We first identified sequence variants within a linkage disequilibrium block (r2 > 0.98) in the intron 5 of cyclin-dependent kinase 5 regulatory subunit-associated protein 1-like 1 (CDKAL1) gene using 4,275 normoglycemic subjects of Cohort 1 (P < 2.5 x 10-8). The association was replicated in 3,782 normoglycemic subjects of Cohort 2. Furthermore, the sequence variants were also associated with glucose levels after oral glucose tolerance test. Especially, a strong association with 1 h glucose (P = 1.3 x 10-11) led us to interpreting that CDKAL1 might influence the level of glycosylated hemoglobin by affecting 1 h glucose level. Ultimately, accumulated effects on the glycosylated hemoglobin level by the genetic variation of CDKAL1 might affect susceptibility to type 2 diabetes mellitus. Hum Mutat 33:655659, 2012. (c) 2012 Wiley Periodicals, Inc.
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Collections - College of Natural Sciences > School of Systems and Biomedical Science > 1. Journal Articles
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