Heterogeneous genetic associations of nucleotide sequence variants with bone mineral density by gender
DC Field | Value | Language |
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dc.contributor.author | Woo, Jiyoung | - |
dc.contributor.author | Kim, Younyoung | - |
dc.contributor.author | Lee, Chaeyoung | - |
dc.date.available | 2018-05-10T05:25:48Z | - |
dc.date.created | 2018-04-17 | - |
dc.date.issued | 2012-03 | - |
dc.identifier.issn | 0301-4851 | - |
dc.identifier.uri | http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/12481 | - |
dc.description.abstract | We examined genetic associations of previously identified sequence variants with bone mineral density and their heterogeneity by gender. Large-scale cohort data were used including a total of 8,419 subjects (4,034 males and 4,385 females) from the Korean Association REsource (KARE) cohort. Bone speed of sound (SOS) values were measured at distal radius or mid-shaft tibia by quantitative ultrasound. Genotypic associations of SOS were tested with each of nucleotide sequence variants identified by previous studies. The genetic association analysis revealed that 2 out of 11 nucleotide sequence variants were associated with SOS (rs1721400, rs7776725, P < 7.58 x 10(-4)). Further analysis with partitioning data by gender showed that the mid-shaft tibia phenotypes were associated with the rs1721400 and rs7776725 in females (P < 3.79 x 10(-4)), but not in males (P > 3.79 x 10(-4)). The current study suggested female-specific associations of rs1721400 and rs7776725 with bone mineral density and heterogeneity of genetic association by skeletal site measured for bone mineral density. | - |
dc.publisher | SPRINGER | - |
dc.relation.isPartOf | MOLECULAR BIOLOGY REPORTS | - |
dc.subject | GENOME-WIDE ASSOCIATION | - |
dc.subject | OSTEOPOROSIS | - |
dc.subject | FRACTURES | - |
dc.title | Heterogeneous genetic associations of nucleotide sequence variants with bone mineral density by gender | - |
dc.type | Article | - |
dc.identifier.doi | 10.1007/s11033-011-0975-z | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | MOLECULAR BIOLOGY REPORTS, v.39, no.3, pp.2259 - 2265 | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000301107800023 | - |
dc.identifier.scopusid | 2-s2.0-84862818177 | - |
dc.citation.endPage | 2265 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 2259 | - |
dc.citation.title | MOLECULAR BIOLOGY REPORTS | - |
dc.citation.volume | 39 | - |
dc.contributor.affiliatedAuthor | Lee, Chaeyoung | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Bone mineral density | - |
dc.subject.keywordAuthor | FAM3C | - |
dc.subject.keywordAuthor | Heterogeneous genetic association | - |
dc.subject.keywordAuthor | Osteoporosis | - |
dc.subject.keywordPlus | GENOME-WIDE ASSOCIATION | - |
dc.subject.keywordPlus | OSTEOPOROSIS | - |
dc.subject.keywordPlus | FRACTURES | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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