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Infrared spectroscopy characterization of normal and lung cancer cells originated from epithelium

Authors
Lee, So YeongYoon, Kyong-AhJang, Soo HwaGanbold, Erdene OchirUuriintuya, DembereldorjShin, Sang-MoRyu, Pan DongJoo, Sang-Woo
Issue Date
Dec-2009
Publisher
KOREAN SOC VETERINARY SCIENCE
Keywords
cancer cell screening; cell monitoring; infrared spectroscopy; lung cancers; phosphorylation
Citation
JOURNAL OF VETERINARY SCIENCE, v.10, no.4, pp.299 - 304
Journal Title
JOURNAL OF VETERINARY SCIENCE
Volume
10
Number
4
Start Page
299
End Page
304
URI
http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/15730
DOI
10.4142/jvs.2009.10.4.299
ISSN
1229-845X
Abstract
The vibrational spectral differences of normal and lung cancer cells were studied for the development of effective cancer cell screening by means of attenuated total reflection infrared spectroscopy. The phosphate monoester symmetric stretching v(s)(PO32-) band intensity at similar to 970 cm(-1) and the phosphodiester symmetric stretching v(s)(PO2-) band intensity at similar to 1,085 cm(-1) in nucleic acids and phospholipids appeared to be significantly strengthened in lung cancer cells with respect to the other vibrational bands compared to normal cells. This finding suggests that more extensive phosphorylation occur in cancer cells. These results demonstrate that lung cancer cells may be prescreened using infrared spectroscopy tools.
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