Synergistic OX40 and CD30 signals sustain CD8(+) T cells during antigenic challenge
DC Field | Value | Language |
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dc.contributor.author | Bekiaris, Vasileios | - |
dc.contributor.author | Gaspal, Fabrina | - |
dc.contributor.author | Kim, Mi-Yeon | - |
dc.contributor.author | Withers, David R. | - |
dc.contributor.author | Sweet, Clive | - |
dc.contributor.author | Anderson, Graham | - |
dc.contributor.author | Lane, Peter J. L. | - |
dc.date.available | 2018-05-10T15:18:33Z | - |
dc.date.created | 2018-04-17 | - |
dc.date.issued | 2009-08 | - |
dc.identifier.issn | 0014-2980 | - |
dc.identifier.uri | http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/15808 | - |
dc.description.abstract | Prior to acquiring a memory phenotype, antigen-activated CD8(+) T cells need to expand and then undergo a contraction phase. Utilizing two different antigenic stimuli, we provide evidence that the tumor necrosis factor receptors OX40 and CD30 integrate synergistic signals during the expansion phase to help maintain CD8(+) effectors. Thus, double deficiency in OX40 and CD30 leads to CD8(+) cell loss during expansion after immunization either with OVA or with murine CMV. Following their contraction, OX40- and CD30-deficient CD8(+) T cells persist normally in CMV-infected mice. In contrast, persistence after OVA challenge is dependent on OX40 and CD30. Collectively, our data define the important role of both OX40 and CD30 during CD8(+) T-cell activation, and show that long-term CD8 persistence after contraction is regulated not only by stimulatory receptors but also by the nature of the antigen or how the antigen is presented. | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.relation.isPartOf | EUROPEAN JOURNAL OF IMMUNOLOGY | - |
dc.subject | VIRAL-INFECTION | - |
dc.subject | RESPONSES | - |
dc.subject | MEMORY | - |
dc.subject | 4-1BB | - |
dc.subject | MICE | - |
dc.subject | CD4 | - |
dc.subject | COSTIMULATION | - |
dc.subject | EXPRESSION | - |
dc.subject | DIFFERENTIATION | - |
dc.subject | CYTOMEGALOVIRUS | - |
dc.title | Synergistic OX40 and CD30 signals sustain CD8(+) T cells during antigenic challenge | - |
dc.type | Article | - |
dc.identifier.doi | 10.1002/eji.200939424 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | EUROPEAN JOURNAL OF IMMUNOLOGY, v.39, no.8, pp.2120 - 2125 | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000269396100025 | - |
dc.identifier.scopusid | 2-s2.0-70249091483 | - |
dc.citation.endPage | 2125 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 2120 | - |
dc.citation.title | EUROPEAN JOURNAL OF IMMUNOLOGY | - |
dc.citation.volume | 39 | - |
dc.contributor.affiliatedAuthor | Kim, Mi-Yeon | - |
dc.type.docType | Article | - |
dc.description.oadoiVersion | published | - |
dc.subject.keywordAuthor | CD8 | - |
dc.subject.keywordAuthor | CD30 | - |
dc.subject.keywordAuthor | OX40 | - |
dc.subject.keywordPlus | VIRAL-INFECTION | - |
dc.subject.keywordPlus | RESPONSES | - |
dc.subject.keywordPlus | MEMORY | - |
dc.subject.keywordPlus | 4-1BB | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | CD4 | - |
dc.subject.keywordPlus | COSTIMULATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | CYTOMEGALOVIRUS | - |
dc.description.journalRegisteredClass | scopus | - |
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