Oil-free generation of small polymeric particles using a coaxial microfluidic channel
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shin, S. | - |
dc.contributor.author | Hong, J.S. | - |
dc.contributor.author | Lee, K.-H. | - |
dc.contributor.author | Lee, S.-H. | - |
dc.date.available | 2018-05-10T15:50:09Z | - |
dc.date.created | 2018-04-17 | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0743-7463 | - |
dc.identifier.uri | http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/16629 | - |
dc.description.abstract | In this study, a microfluidic method to generate small polymeric particles (10 μm in diameter) via the control of interfacial tension without using oil and in situ photopolymerization immediately after drop generation was introduced. For the reduction in size, the selection of proper sample and sheath liquid to minimize the interfacial tension is extremely important, and 4-HBA (4-hydroxybutyl acrylate) andPVA(poly(vinyl acrylate)) were employed as core and sheath fluid pair because of much smaller surface tension than the case using oil. In addition, PVA is easily washable by aqueous solution, which is a strong advantage when the particle is applied in biomedical fields. The viscosity effect of sheath flow was also examined for further size reduction. The loading and release properties of proteins were evaluated using fluorescently labeled bovine serum albumin for the potential application as drug carrier. The protein was uniformly loaded into particles, and the protein release rate was dependent on the particle size. For utility in the biomedical area, the cyto-compatibility test of 4-HBA was performed by culturing glioma cells on the 4-HBA sheet, and the cells were alive well after 4 days culture. Conclusively, this oil-free particle generation methods facilitates the generation of uniform and small particles in a simple way without an oil-washing process. © 2009 American Chemical Society. | - |
dc.relation.isPartOf | Langmuir | - |
dc.subject | Biomedical fields | - |
dc.subject | Bovine serum albumins | - |
dc.subject | Cytocompatibility | - |
dc.subject | Drop generation | - |
dc.subject | Drug carrier | - |
dc.subject | Glioma cells | - |
dc.subject | In-situ | - |
dc.subject | Microfluidic channel | - |
dc.subject | Microfluidic method | - |
dc.subject | Particle generation | - |
dc.subject | Polymeric particles | - |
dc.subject | Potential applications | - |
dc.subject | Protein release | - |
dc.subject | Release property | - |
dc.subject | Sheath flows | - |
dc.subject | Size reductions | - |
dc.subject | Small particles | - |
dc.subject | Vinyl acrylates | - |
dc.subject | Viscosity effects | - |
dc.subject | Body fluids | - |
dc.subject | Cell culture | - |
dc.subject | Photopolymerization | - |
dc.subject | Proteins | - |
dc.subject | Surface tension | - |
dc.subject | Microfluidics | - |
dc.subject | 4 hydroxybutyl acrylate | - |
dc.subject | 4-hydroxybutyl acrylate | - |
dc.subject | acrylic acid derivative | - |
dc.subject | bovine serum albumin | - |
dc.subject | microsphere | - |
dc.subject | oil | - |
dc.subject | polymer | - |
dc.subject | water | - |
dc.subject | animal | - |
dc.subject | article | - |
dc.subject | cattle | - |
dc.subject | chemistry | - |
dc.subject | metabolism | - |
dc.subject | microfluidic analysis | - |
dc.subject | particle size | - |
dc.subject | surface tension | - |
dc.subject | tumor cell line | - |
dc.subject | ultraviolet radiation | - |
dc.subject | Acrylates | - |
dc.subject | Animals | - |
dc.subject | Cattle | - |
dc.subject | Cell Line, Tumor | - |
dc.subject | Microfluidic Analytical Techniques | - |
dc.subject | Microspheres | - |
dc.subject | Oils | - |
dc.subject | Particle Size | - |
dc.subject | Polymers | - |
dc.subject | Serum Albumin, Bovine | - |
dc.subject | Surface Tension | - |
dc.subject | Ultraviolet Rays | - |
dc.subject | Water | - |
dc.title | Oil-free generation of small polymeric particles using a coaxial microfluidic channel | - |
dc.type | Article | - |
dc.identifier.doi | 10.1021/la901657z | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | Langmuir, v.25, no.20, pp.12361 - 12366 | - |
dc.description.journalClass | 1 | - |
dc.identifier.scopusid | 2-s2.0-74949103657 | - |
dc.citation.endPage | 12366 | - |
dc.citation.number | 20 | - |
dc.citation.startPage | 12361 | - |
dc.citation.title | Langmuir | - |
dc.citation.volume | 25 | - |
dc.contributor.affiliatedAuthor | Hong, J.S. | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scopus | - |
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