Roles of embryonic and adult lymphoid tissue inducer cells in primary and secondary lymphoid tissues
DC Field | Value | Language |
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dc.contributor.author | Kim, Mi-Yeon | - |
dc.date.available | 2018-05-10T15:59:37Z | - |
dc.date.created | 2018-04-17 | - |
dc.date.issued | 2008-06-30 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/16849 | - |
dc.description.abstract | The nomenclature "embryonic lymphoid tissue inducer (LTi) cell" reflects the fundamental role of the cell in secondary lymphoid tissue organization. In addition, it is equally important in primary lymphoid tissue development as it regulates central tolerance to self-antigens in the thymus. An adult LTi cell constitutively expresses two sets of tumor necrosis factor (TNF) family members, whereas its embryonic counterpart expresses only one. The first set is lymphotoxin (LT)a, LT beta, and TNFa, which are essential for the secondary lymphoid organogenesis during embryogenesis and for maintaining an organized secondary lymphoid structure during adulthood. The second set is OX40- and CD30-ligands, which are critical for memory T cell generation. Adult LTi cells regulate adaptive immune responses by providing LT R signals to stromal cells to maintain secondary lymphoid tissue structure, and determine adaptive immune responses by providing OX40 and CD30 survival signals to activated T cells in memory T cell generation. Along with the consideration of the roles of embryonic LTi cells in primary and secondary lymphoid tissues, this review highlights the roles of adult LTi cells in secondary lymphoid tissue function. | - |
dc.publisher | YONSEI UNIV COLLEGE MEDICINE | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.subject | TUMOR-NECROSIS-FACTOR | - |
dc.subject | CD4(+)CD3(-) CELLS | - |
dc.subject | T-CELL | - |
dc.subject | ORGAN DEVELOPMENT | - |
dc.subject | PEYERS-PATCHES | - |
dc.subject | B-CELL | - |
dc.subject | ANTIBODY-RESPONSES | - |
dc.subject | LYMPHOTOXIN-ALPHA | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | MICE DEFICIENT | - |
dc.title | Roles of embryonic and adult lymphoid tissue inducer cells in primary and secondary lymphoid tissues | - |
dc.type | Article | - |
dc.identifier.doi | 10.3349/ymj.2008.49.3.352 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, v.49, no.3, pp.352 - 356 | - |
dc.identifier.kciid | ART001250025 | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000257277000002 | - |
dc.identifier.scopusid | 2-s2.0-48649105734 | - |
dc.citation.endPage | 356 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 352 | - |
dc.citation.title | YONSEI MEDICAL JOURNAL | - |
dc.citation.volume | 49 | - |
dc.contributor.affiliatedAuthor | Kim, Mi-Yeon | - |
dc.type.docType | Review | - |
dc.description.oadoiVersion | published | - |
dc.subject.keywordAuthor | lymphoid tissue inducer cell | - |
dc.subject.keywordAuthor | secondary lymphoid tissue | - |
dc.subject.keywordAuthor | thymus | - |
dc.subject.keywordPlus | TUMOR-NECROSIS-FACTOR | - |
dc.subject.keywordPlus | CD4(+)CD3(-) CELLS | - |
dc.subject.keywordPlus | T-CELL | - |
dc.subject.keywordPlus | ORGAN DEVELOPMENT | - |
dc.subject.keywordPlus | PEYERS-PATCHES | - |
dc.subject.keywordPlus | B-CELL | - |
dc.subject.keywordPlus | ANTIBODY-RESPONSES | - |
dc.subject.keywordPlus | LYMPHOTOXIN-ALPHA | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | MICE DEFICIENT | - |
dc.description.journalRegisteredClass | scopus | - |
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