Protective effect of maghemite nanoparticles on ultraviolet-induced photo-damage in human skin fibroblasts
- Authors
- Lee, Kwon-Jai; An, Jeung-Hee; Shin, Jae-Soo; Kim, Dong-Hee; Kim, Changman; Ozaki, Hajime; Koh, Jae-Gui
- Issue Date
- 21-Nov-2007
- Publisher
- IOP PUBLISHING LTD
- Citation
- NANOTECHNOLOGY, v.18, no.46
- Journal Title
- NANOTECHNOLOGY
- Volume
- 18
- Number
- 46
- URI
- http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/17726
- DOI
- 10.1088/0957-4484/18/46/465201
- ISSN
- 0957-4484
- Abstract
- This study examined the optical properties of an oxidized form of maghemite (gamma-Fe2O3) nanoparticles and their protective effects against the photoaging of human skin fibroblasts irradiated with ultraviolet (UV) light. Nanoparticles with diameters ranging from 8.7 to 12 nm were prepared using a chemical co-precipitation method. The nanoparticles were coated with two surfactants to obtain a water-based product. The onset of the absorption of the. gamma-Fe2O3 nanoparticles in the UV-visible absorption spectra increased with increasing particle size. The. gamma-Fe2O3 nanoparticles significantly inhibited the production of matrix metalloproteinase-1 in human skin fibroblast HS 68 cells by 60% compared with the UV-irradiated control. These results suggest that gamma-Fe2O3 nanoparticles have photoprotective properties, and have potential use as an agent against photoaging.
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