AIDS환자 치료를 위한 NvBAT 치료기법: RTI에 대한 PI의 우수성

Abstract

- In this paper, we study the NvBAT treatment for AIDS patients that is combined with PI rather than RTI, while the previous results have been focused on the NvBAT in conjuction with RTI. To this end, we obtain a bifurcation diagram which shows a change in the equilibrium points, and in their stability properties as the PI drug effect is varied. Based on the bifurcation diagram, we show that the NvBAT can be combined with drug PI for the treatment of AIDS patients. Various computer simulation results are included, which show the superiority of the NvBAT with PI over that with RTI. Accordition to simulation result, the NvBAT combined with PI is able to keep virus load level lower than that combined with RTI, which is crucial to avoid the emergence of drug-resistant mutants. Moreover, it is shown that, for some AIDS patients, NvBAT with RTI cannot make patients into long term non-progressor, while NvBAT with PI can.