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ChimerDB - Database of Chimeric Sequences in the GenBank
- Authors
- Lee Sanghyuk; Kim Namshin; 신석민; Cho Kwang-Hwi
- Issue Date
- Jun-2004
- Publisher
- 한국유전체학회
- Keywords
- chimeric sequence; chromosomal translocation; trans-splicing; multi-locus transcription; chimeric sequence; chromosomal translocation; trans-splicing; multi-locus transcription
- Citation
- Genomics & Informatics, v.2, no.2, pp.61 - 66
- Journal Title
- Genomics & Informatics
- Volume
- 2
- Number
- 2
- Start Page
- 61
- End Page
- 66
- ISSN
- 1598-866X
- Abstract
- Fusion proteins resulting from chimeric sequences are excelent targets for therapeutic drug development. We developed a database of chimeric sequences by examining the genomic alignment of mRNA and EST sequences in the GenBank. We identified 688 chimeric mRNA and 20,998 chimeric EST sequences. Including EST sequences greatly expands the scope of chimeric sequences even though it inevitably accompanies many artifacts. Chimeric sequences are clustered according to the ECgene ID so that the user can easily find chimeric sequences related to a specific gene. Alignments of chimeric sequences are displayed as custom tracks in the UCSC genome browser. ChimerDB, available at http:/genome.ewha.ac.kr/ECgene/ChimerDB/, should be a valuable resource for finding drug targets to treat cancers.
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Related Researcher
- Cho, Kwang Hwi
- College of Natural Sciences (Department of Bioinformatics & Life Science)