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Cited 45 time in webofscience Cited 45 time in scopus
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Proteogenomic Characterization of Human Early-Onset Gastric Cancer

Authors
Mun, D.-G.Bhin, J.Kim, S.Kim, H.Jung, J.H.Jung, Y.Jang, Y.E.Park, J.M.Kim, H.Jung, Y.Lee, H.Bae, J.Back, S.Kim, S.Kim, J.Park, H.Li, H.Hwang, K.-B.Park, Y.S.Yook, J.H.Kim, B.S.Kwon, S.Y.Ryu, S.W.Park, D.Jeon, T.Y.Kim, D.H.Lee, J.-H.Han, S.-U.Song, K.S.Park, D.Park, J.W.Rodriguez, H.Kim, J.Lee, H.Kim, K.P.Yang, E.G.Kim, H.Paek, E.Lee, S.Lee, S.Hwang, D.
Issue Date
Jan-2019
Publisher
Cell Press
Keywords
cancer subtypes; correlation between mRNA and protein abundance changes; correlation between mutation and phosphorylation; diffuse gastric cancer; proteogenomics; somatic nonsynonymous mutations
Citation
Cancer Cell, v.35, no.1, pp.111 - 124.e10
Journal Title
Cancer Cell
Volume
35
Number
1
Start Page
111
End Page
124.e10
URI
http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/30842
DOI
10.1016/j.ccell.2018.12.003
ISSN
1535-6108
Abstract
We report proteogenomic analysis of diffuse gastric cancers (GCs) in young populations. Phosphoproteome data elucidated signaling pathways associated with somatic mutations based on mutation-phosphorylation correlations. Moreover, correlations between mRNA and protein abundances provided potential oncogenes and tumor suppressors associated with patient survival. Furthermore, integrated clustering of mRNA, protein, phosphorylation, and N-glycosylation data identified four subtypes of diffuse GCs. Distinguishing these subtypes was possible by proteomic data. Four subtypes were associated with proliferation, immune response, metabolism, and invasion, respectively; and associations of the subtypes with immune- and invasion-related pathways were identified mainly by phosphorylation and N-glycosylation data. Therefore, our proteogenomic analysis provides additional information beyond genomic analyses, which can improve understanding of cancer biology and patient stratification in diffuse GCs. © 2018 Elsevier Inc.Mun et al. perform proteogenomic analysis of diffuse gastric cancers (DGC) in a young population, identifying that correlations of mRNA-protein abundance associate with survival and defining four subtypes of DGC. The associations of some subtypes with related pathways are identified mainly by the proteomic data.
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