Atrial fibrillation genetic risk differentiates cardioembolic stroke from other stroke subtypes
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dc.contributor.author | Pulit, Sara L. | - |
dc.contributor.author | Weng, Lu-Chen | - |
dc.contributor.author | McArdle, Patrick F. | - |
dc.contributor.author | Trinquart, Ludovic | - |
dc.contributor.author | Choi, Seung Hoan | - |
dc.contributor.author | Mitchell, Braxton D. | - |
dc.contributor.author | Rosand, Jonathan | - |
dc.contributor.author | de Bakker, Paul I. W. | - |
dc.contributor.author | Benjamin, Emelia J. | - |
dc.contributor.author | Ellinor, Patrick T. | - |
dc.contributor.author | Kittner, Steven J. | - |
dc.contributor.author | Lubitz, Steven A. | - |
dc.contributor.author | Anderson, Christopher D. | - |
dc.contributor.author | Christophersen, Ingrid E. | - |
dc.contributor.author | Rienstra, Michiel | - |
dc.contributor.author | Roselli, Carolina | - |
dc.contributor.author | Yin, Xiaoyan | - |
dc.contributor.author | Geelhoed, Bastiaan | - |
dc.contributor.author | Barnard, John | - |
dc.contributor.author | Lin, Honghuang | - |
dc.contributor.author | Arking, Dan E. | - |
dc.contributor.author | Smith, Albert, V | - |
dc.contributor.author | Albert, Christine M. | - |
dc.contributor.author | Chaffin, Mark | - |
dc.contributor.author | Tucker, Nathan R. | - |
dc.contributor.author | Li, Molong | - |
dc.contributor.author | Klarin, Derek | - |
dc.contributor.author | Bihlmeyer, Nathan A. | - |
dc.contributor.author | Low, Siew-Kee | - |
dc.contributor.author | Weeke, Peter E. | - |
dc.contributor.author | Mueller-Nurasyid, Martina | - |
dc.contributor.author | Smith, J. Gustav | - |
dc.contributor.author | Brody, Jennifer A. | - |
dc.contributor.author | Niemeijer, Maartje N. | - |
dc.contributor.author | Doerr, Marcus | - |
dc.contributor.author | Trompet, Stella | - |
dc.contributor.author | Huffman, Jennifer | - |
dc.contributor.author | Gustafsson, Stefan | - |
dc.contributor.author | Schurmann, Claudia | - |
dc.contributor.author | Kleber, Marcus E. | - |
dc.contributor.author | Lyytikainen, Leo-Pekka | - |
dc.contributor.author | Seppala, Ilkka | - |
dc.contributor.author | Malik, Rainer | - |
dc.contributor.author | Horimoto, Andrea R. V. R. | - |
dc.contributor.author | Perez, Marco | - |
dc.contributor.author | Sinisalo, Juha | - |
dc.contributor.author | Aeschbacher, Stefanie | - |
dc.contributor.author | Theriault, Sebastien | - |
dc.contributor.author | Yao, Jie | - |
dc.contributor.author | Radmanesh, Farid | - |
dc.contributor.author | Weiss, Stefan | - |
dc.contributor.author | Teumer, Alexander | - |
dc.contributor.author | Clauss, Sebastian | - |
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dc.contributor.author | Rader, Daniel J. | - |
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dc.contributor.author | Sun, Albert | - |
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dc.contributor.author | Kubo, Michiaki | - |
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dc.contributor.author | Launer, Lenore J. | - |
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dc.contributor.author | Loos, Ruth J. F. | - |
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dc.contributor.author | Lokki, Marja-Liisa | - |
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dc.contributor.author | Pereira, Alexandre | - |
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dc.contributor.author | Wang, Xingwu | - |
dc.contributor.author | Selim, Magdy | - |
dc.contributor.author | Pikula, Aleksandra | - |
dc.contributor.author | Wolf, Philip | - |
dc.contributor.author | Seshadri, Sudha | - |
dc.contributor.author | de Bakker, Paul | - |
dc.contributor.author | Chasman, Daniel | - |
dc.contributor.author | Rexrode, Kathryn | - |
dc.contributor.author | Chen, Ida | - |
dc.contributor.author | Rotter, Jerome | - |
dc.contributor.author | Luke, May | - |
dc.contributor.author | Sale, Michelle | - |
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dc.contributor.author | Lebedeva, Elena | - |
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dc.contributor.author | Jood, Katarina | - |
dc.contributor.author | Olsson, Sandra | - |
dc.contributor.author | Kim, Helen | - |
dc.contributor.author | Lee, Chaeyoung | - |
dc.contributor.author | Kilarski, Laura | - |
dc.contributor.author | Markus, Hugh | - |
dc.contributor.author | Peycke, Jennifer | - |
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dc.contributor.author | Chiou, Hung Yi | - |
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dc.contributor.author | Howard, George | - |
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dc.contributor.author | O'Connell, Jeff | - |
dc.contributor.author | Milewicz, Dianna | - |
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dc.contributor.author | Karaszewski, Bartosz | - |
dc.contributor.author | Werring, David | - |
dc.contributor.author | Sofat, Reecha | - |
dc.contributor.author | Smalley, June | - |
dc.contributor.author | Lindgren, Arne | - |
dc.contributor.author | Hansen, Bjorn | - |
dc.contributor.author | Norrving, Bo | - |
dc.contributor.author | Smith, Gustav | - |
dc.contributor.author | Jose Martin, Juan | - |
dc.contributor.author | Thijs, Vincent | - |
dc.contributor.author | Klijn, Karin | - |
dc.contributor.author | van't Hof, Femke | - |
dc.contributor.author | Algra, Ale | - |
dc.contributor.author | Macleod, Mary | - |
dc.contributor.author | Perry, Rodney | - |
dc.contributor.author | Arnett, Donna | - |
dc.contributor.author | Pezzini, Alessandro | - |
dc.contributor.author | Padovani, Alessandro | - |
dc.contributor.author | Cramer, Steve | - |
dc.contributor.author | Fisher, Mark | - |
dc.contributor.author | Saleheen, Danish | - |
dc.contributor.author | Broderick, Joseph | - |
dc.contributor.author | Kissela, Brett | - |
dc.contributor.author | Doney, Alex | - |
dc.contributor.author | Sudlow, Cathie | - |
dc.contributor.author | Rannikmae, Kristiina | - |
dc.contributor.author | Silliman, Scott | - |
dc.contributor.author | McDonough, Caitrin | - |
dc.contributor.author | Walters, Matthew | - |
dc.contributor.author | Pedersen, Annie | - |
dc.contributor.author | Nakagawa, Kazuma | - |
dc.contributor.author | Chang, Christy | - |
dc.contributor.author | Dobbins, Mark | - |
dc.contributor.author | McArdle, Patrick | - |
dc.contributor.author | Chang, Yu-Ching | - |
dc.contributor.author | Brown, Robert | - |
dc.contributor.author | Brown, Devin | - |
dc.contributor.author | Holliday, Elizabeth | - |
dc.contributor.author | Kalaria, Raj | - |
dc.contributor.author | Maguire, Jane | - |
dc.contributor.author | Attia, John | - |
dc.contributor.author | Farrall, Martin | - |
dc.contributor.author | Giese, Anne-Katrin | - |
dc.contributor.author | Fornage, Myriam | - |
dc.contributor.author | Majersik, Jennifer | - |
dc.contributor.author | Cushman, Mary | - |
dc.contributor.author | Keene, Keith | - |
dc.contributor.author | Bennett, Siiri | - |
dc.contributor.author | Tirschwell, David | - |
dc.contributor.author | Psaty, Bruce | - |
dc.contributor.author | Reiner, Alex | - |
dc.contributor.author | Longstreth, Will | - |
dc.contributor.author | Spence, David | - |
dc.contributor.author | Montaner, Joan | - |
dc.contributor.author | Fernandez-Cadenas, Israel | - |
dc.contributor.author | Langefeld, Carl | - |
dc.contributor.author | Bushnell, Cheryl | - |
dc.contributor.author | Heitsch, Laura | - |
dc.contributor.author | Lee, Jin-Moo | - |
dc.contributor.author | Sheth, Kevin | - |
dc.date.available | 2019-03-13T01:12:41Z | - |
dc.date.created | 2019-02-19 | - |
dc.date.issued | 2018-12 | - |
dc.identifier.issn | 2376-7839 | - |
dc.identifier.uri | http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/30853 | - |
dc.description.abstract | Objective We sought to assess whether genetic risk factors for atrial fibrillation (AF) can explain cardioembolic stroke risk. Methods We evaluated genetic correlations between a previous genetic study of AF and AF in the presence of cardioembolic stroke using genome-wide genotypes from the Stroke Genetics Network (N = 3,190 AF cases, 3,000 cardioembolic stroke cases, and 28,026 referents). We tested whether a previously validated AF polygenic risk score (PRS) associated with cardioembolic and other stroke subtypes after accounting for AF clinical risk factors. Results We observed a strong correlation between previously reported genetic risk for AF, AF in the presence of stroke, and cardioembolic stroke (Pearson r = 0.77 and 0.76, respectively, across SNPs with p < 4.4 x 10(-4) in the previous AF meta-analysis). An AF PRS, adjusted for clinical AF risk factors, was associated with cardioembolic stroke (odds ratio [OR] per SD = 1.40, p = 1.45 x 10(-48)), explaining similar to 20% of the heritable component of cardioembolic stroke risk. The AF PRS was also associated with stroke of undetermined cause (OR per SD = 1.07,p = 0.004), but no other primary stroke subtypes (all p > 0.1). Conclusions Genetic risk of AF is associated with cardioembolic stroke, independent of clinical risk factors. Studies are warranted to determine whether AF genetic risk can serve as a biomarker for strokes caused by AF. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.relation.isPartOf | NEUROLOGY-GENETICS | - |
dc.title | Atrial fibrillation genetic risk differentiates cardioembolic stroke from other stroke subtypes | - |
dc.type | Article | - |
dc.identifier.doi | 10.1212/NXG.0000000000000293 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | NEUROLOGY-GENETICS, v.4, no.6 | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000455099800017 | - |
dc.identifier.scopusid | 2-s2.0-85060844769 | - |
dc.citation.number | 6 | - |
dc.citation.title | NEUROLOGY-GENETICS | - |
dc.citation.volume | 4 | - |
dc.contributor.affiliatedAuthor | Lee, Chaeyoung | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.oadoiVersion | published | - |
dc.subject.keywordPlus | ISCHEMIC-STROKE | - |
dc.subject.keywordPlus | CAUSATIVE CLASSIFICATION | - |
dc.subject.keywordPlus | LIFETIME RISK | - |
dc.subject.keywordPlus | EPIDEMIOLOGY | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | PREVENTION | - |
dc.subject.keywordPlus | VARIANTS | - |
dc.subject.keywordPlus | ASPIRIN | - |
dc.subject.keywordPlus | BURDEN | - |
dc.description.journalRegisteredClass | scopus | - |
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