Anti-inflammatory effects of luteolin: A review of in vitro, in vivo, and in silico studies
DC Field | Value | Language |
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dc.contributor.author | Aziz, N. | - |
dc.contributor.author | Kim, M.-Y. | - |
dc.contributor.author | Cho, J.Y. | - |
dc.date.available | 2019-03-13T01:32:29Z | - |
dc.date.created | 2018-09-12 | - |
dc.date.issued | 2018-10 | - |
dc.identifier.issn | 0378-8741 | - |
dc.identifier.uri | http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/31173 | - |
dc.description.abstract | Ethnopharmacological relevance: Luteolin (3′, 4′, 5,7-tetrahydroxyflavone) has been identified as commonly present in plants. Plants with a high luteolin content have been used ethnopharmacologically to treat inflammation-related symptoms. Both isolated luteolin and extracts from luteolin-rich plants have been studied using various models and exhibited anti-inflammatory activity. Aim of the review: This paper uses recent research findings with a broad range of study models to describe the anti-inflammatory activity of luteolin, particularly its mechanisms at the molecular level; provide guidance for future research; and evaluate the feasibility of developing luteolin into an anti-inflammatory drug. Materials and methods: We summarize reports about the anti-inflammatory activity of luteolin published since 2009, which we found in MEDLINE/PubMed, Scopus, Web of Knowledge, and Google Scholar. To acquire broad information, we extended our search to online FDA documents. Results: Luteolin is a flavonoid commonly found in medicinal plants and has strong anti-inflammatory activity in vitro and in vivo. Some of its derivatives, such as luteolin-7-O-glucoside, have also shown anti-inflammatory activity. The action mechanism of luteolin varies, but Src in the nuclear factor (NF)-κB pathway, MAPK in the activator protein (AP)− 1 pathway, and SOCS3 in the signal transducer and activator of transcription 3 (STAT3) pathway are its major target transcription factors. A clinical trial with a formulation containing luteolin showed excellent therapeutic effect against inflammation-associated diseases. Conclusion: In silico, in vitro, in vivo, and clinical studies strongly suggest that the major pharmacological mechanism of luteolin is its anti-inflammatory activity, which derives from its regulation of transcription factors such as STAT3, NF-κB, and AP-1. Much work remains to ensure the safety, quality, and efficacy of luteolin before it can be used to treat inflammation-related diseases in humans. © 2018 Elsevier B.V. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Elsevier Ireland Ltd | - |
dc.relation.isPartOf | Journal of Ethnopharmacology | - |
dc.title | Anti-inflammatory effects of luteolin: A review of in vitro, in vivo, and in silico studies | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.jep.2018.05.019 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | Journal of Ethnopharmacology | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000442060400033 | - |
dc.identifier.scopusid | 2-s2.0-85047256115 | - |
dc.citation.title | Journal of Ethnopharmacology | - |
dc.contributor.affiliatedAuthor | Kim, M.-Y. | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0378874117334578 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.subject.keywordAuthor | Luteolin | - |
dc.subject.keywordAuthor | Flavonoid | - |
dc.subject.keywordAuthor | Inflammatory diseases | - |
dc.subject.keywordAuthor | Inflammatory signaling | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | AUTISM SPECTRUM DISORDERS | - |
dc.subject.keywordPlus | ACTIVATED PROTEIN-KINASES | - |
dc.subject.keywordPlus | ACUTE LUNG INJURY | - |
dc.subject.keywordPlus | RAW 264.7 CELLS | - |
dc.subject.keywordPlus | INFLAMMATORY RESPONSES | - |
dc.subject.keywordPlus | FLAVONOID LUTEOLIN | - |
dc.subject.keywordPlus | LYCHNOPHORA TRICHOCARPHA | - |
dc.subject.keywordPlus | BIOLOGICAL-ACTIVITIES | - |
dc.subject.keywordPlus | SIGNALING PATHWAYS | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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