The death domain superfamily in intracellular signaling of apoptosis and inflammation
- Authors
- Park, Hyun Ho; Lo, Yu-Chih; Lin, Su-Chang; Wang, Liwei; Yang, Jin Kuk; Wu, Hao
- Issue Date
- Apr-2007
- Publisher
- ANNUAL REVIEWS
- Keywords
- death domain (DD); death effector domain (DED); tandem DED; caspase recruitment domain (CARD); pyrin domain (PYD); crystal structure; NMR structure
- Citation
- ANNUAL REVIEW OF IMMUNOLOGY, v.25, pp.561 - 586
- Journal Title
- ANNUAL REVIEW OF IMMUNOLOGY
- Volume
- 25
- Start Page
- 561
- End Page
- 586
- URI
- http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/31343
- DOI
- 10.1146/annurev.immunol.25.022106.141656
- ISSN
- 0732-0582
- Abstract
- The death domain (DD) superfamily comprising the death domain (DD) subfamily, the death effector domain (DED) subfamily, the caspase recruitment domain (CARD) subfamily, and the pyrin domain (PYD) subfamily is one of the largest domain superfamilies. By mediating homotypic interactions within each domain subfamily, these proteins play important roles in the assembly and activation of apoptotic and inflammatory complexes. In this chapter, we review the molecular complexes assembled by these proteins, the structural and biochemical features of these domains, and the molecular interactions mediated by diem. By analyzing the potential molecular basis for the function of these domains, we hope to provide a comprehensive understanding of the function, structure, interaction, and evolution of this important family of domains.
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