Dlx1/2 and Otp coordinate the production of hypothalamic GHRH- and AgRP-neurons
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Bora | - |
dc.contributor.author | Kim, Janghyun | - |
dc.contributor.author | An, Taekyeong | - |
dc.contributor.author | Kim, Sangsoo | - |
dc.contributor.author | Patel, Esha M. | - |
dc.contributor.author | Raber, Jacob | - |
dc.contributor.author | Lee, Soo-Kyung | - |
dc.contributor.author | Lee, Seunghee | - |
dc.contributor.author | Lee, Jae W. | - |
dc.date.available | 2019-03-13T01:45:13Z | - |
dc.date.created | 2018-09-12 | - |
dc.date.issued | 2018-05 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/31721 | - |
dc.description.abstract | Despite critical roles of the hypothalamic arcuate neurons in controlling the growth and energy homeostasis, the gene regulatory network directing their development remains unclear. Here we report that the transcription factors Dlx1/2 and Otp coordinate the balanced generation of the two functionally related neurons in the hypothalamic arcuate nucleus, GHRH-neurons promoting the growth and AgRP-neurons controlling the feeding and energy expenditure. Dlx1/2-deficient mice show a loss-of-GHRH-neurons and an increase of AgRP-neurons, and consistently develop dwarfism and consume less energy. These results indicate that Dlx1/2 are crucial for specifying the GHRH-neuronal identity and, simultaneously, for suppressing AgRP-neuronal fate. We further show that Otp is required for the generation of AgRP-neurons and that Dlx1/2 repress the expression of Otp by directly binding the Otp gene. Together, our study demonstrates that the identity of GHRH- and AgRP-neurons is synchronously specified and segregated by the Dlx1/2-Otp gene regulatory axis. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.relation.isPartOf | NATURE COMMUNICATIONS | - |
dc.subject | POMC-EXPRESSING PROGENITORS | - |
dc.subject | ARCUATE NUCLEUS | - |
dc.subject | TRANSCRIPTION FACTORS | - |
dc.subject | DOPAMINERGIC-NEURONS | - |
dc.subject | HOMEOBOX FACTOR | - |
dc.subject | ENERGY-BALANCE | - |
dc.subject | ADIPOSE-TISSUE | - |
dc.subject | FOREBRAIN | - |
dc.subject | GROWTH | - |
dc.subject | MOUSE | - |
dc.title | Dlx1/2 and Otp coordinate the production of hypothalamic GHRH- and AgRP-neurons | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/s41467-018-04377-4 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | NATURE COMMUNICATIONS, v.9 | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000432792100002 | - |
dc.identifier.scopusid | 2-s2.0-85047529530 | - |
dc.citation.title | NATURE COMMUNICATIONS | - |
dc.citation.volume | 9 | - |
dc.contributor.affiliatedAuthor | Kim, Sangsoo | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.oadoiVersion | published | - |
dc.subject.keywordPlus | POMC-EXPRESSING PROGENITORS | - |
dc.subject.keywordPlus | ARCUATE NUCLEUS | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTORS | - |
dc.subject.keywordPlus | DOPAMINERGIC-NEURONS | - |
dc.subject.keywordPlus | HOMEOBOX FACTOR | - |
dc.subject.keywordPlus | ENERGY-BALANCE | - |
dc.subject.keywordPlus | ADIPOSE-TISSUE | - |
dc.subject.keywordPlus | FOREBRAIN | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | MOUSE | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
Soongsil University Library 369 Sangdo-Ro, Dongjak-Gu, Seoul, Korea (06978)02-820-0733
COPYRIGHT ⓒ SOONGSIL UNIVERSITY, ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.