Tuning the Hydrophobicity of a Hydrogel Using Self-Assembled Domains of Polymer Cross-Linkers
DC Field | Value | Language |
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dc.contributor.author | Hee-Jin Kim | - |
dc.contributor.author | Sungwoo Cho | - |
dc.contributor.author | Seung Joo Oh | - |
dc.contributor.author | Sung Gyu Shin | - |
dc.contributor.author | RYU, HEE WOOK | - |
dc.contributor.author | Jeong, Jae Hyun | - |
dc.date.available | 2019-05-20T08:40:02Z | - |
dc.date.created | 2019-05-20 | - |
dc.date.issued | 2019-05 | - |
dc.identifier.issn | 1996-1944 | - |
dc.identifier.uri | http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/34735 | - |
dc.description.abstract | Hydrogels incorporated with hydrophobic motifs have received considerable attention to recapitulate the cellular microenvironments, specifically for the bio-mineralization of a 3D matrix. Introduction of hydrophobic molecules into a hydrogel often results in irregular arrangement of the motifs, and further phase separation of hydrophobic domains, but limited efforts have been made to resolve this challenge in developing the hydrophobically-modified hydrogel. Therefore, this study presents an advanced integrative strategy to incorporate hydrophobic domains regularly in a hydrogel using self-assembled domains formed with polymer cross-linkers, building blocks of a hydrogel. Self-assemblies formed by polymer cross-linkers were examined as micro-domains to incorporate hydrophobic motifs in a hydrogel. The self-assembled structures in a pre-gelled solution were confirmed with the fluorescence analysis and the hydrophobicity of a hydrogel could be tuned by incorporating the hydrophobic chains in a controlled manner. Overall, the results of this study would greatly serve to tuning performance of a wide array of hydrophobically-modified hydrogels in drug delivery, cell therapies and tissue engineering. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI Open Access Publishing | - |
dc.relation.isPartOf | Materials | - |
dc.title | Tuning the Hydrophobicity of a Hydrogel Using Self-Assembled Domains of Polymer Cross-Linkers | - |
dc.type | Article | - |
dc.identifier.doi | 10.3390/ma12101635 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | Materials, v.12, no.10, pp.1635 | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000471012500064 | - |
dc.identifier.scopusid | 2-s2.0-85066871911 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1635 | - |
dc.citation.title | Materials | - |
dc.citation.volume | 12 | - |
dc.contributor.affiliatedAuthor | RYU, HEE WOOK | - |
dc.contributor.affiliatedAuthor | Jeong, Jae Hyun | - |
dc.identifier.url | https://www.mdpi.com/1996-1944/12/10/1635 | - |
dc.description.isOpenAccess | Y | - |
dc.subject.keywordAuthor | Degree of swelling | - |
dc.subject.keywordAuthor | Hydrogel | - |
dc.subject.keywordAuthor | Hydrophobicity | - |
dc.subject.keywordAuthor | Self-assembly | - |
dc.subject.keywordPlus | Cell engineering | - |
dc.subject.keywordPlus | Controlled drug delivery | - |
dc.subject.keywordPlus | Fluorescence | - |
dc.subject.keywordPlus | Hydrogels | - |
dc.subject.keywordPlus | Phase separation | - |
dc.subject.keywordPlus | Polymers | - |
dc.subject.keywordPlus | Self assembly | - |
dc.subject.keywordPlus | Tissue engineering | - |
dc.subject.keywordPlus | Bio mineralizations | - |
dc.subject.keywordPlus | Degree of swelling | - |
dc.subject.keywordPlus | Fluorescence analysis | - |
dc.subject.keywordPlus | Hydrophobic domains | - |
dc.subject.keywordPlus | Hydrophobic molecules | - |
dc.subject.keywordPlus | Irregular arrangement | - |
dc.subject.keywordPlus | Self assembled structures | - |
dc.subject.keywordPlus | Self-assembled domains | - |
dc.subject.keywordPlus | Hydrophobicity | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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