The synergistic effect of biomimetic electrical stimulation and extracellular-matrix-mimetic nanopattern for upregulating cell activities
- Authors
- So, J.-Y.; Lee, J.; Ahn, Y.; Kang, D.; Jung, W.; Bae, W.-G.
- Issue Date
- Nov-2020
- Publisher
- Elsevier Ltd
- Keywords
- Biomimetic electrical stimulation; Cell proliferation; Nanopattern; Wound healing
- Citation
- Biosensors and Bioelectronics, v.167
- Journal Title
- Biosensors and Bioelectronics
- Volume
- 167
- URI
- http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/38594
- DOI
- 10.1016/j.bios.2020.112470
- ISSN
- 0956-5663
- Abstract
- Endogenous bioelectric signaling and the extracellular matrix (ECM) are factors that have a great effect on the performance of cellular functions. Presenting an experimental platform to confirm the synergy effects of an electrical stimulation, which simulates endogenous bioelectricity, and nanopatterns that can be precisely fabricated in various patterns sizes makes it possible to consider those factors effectively. Herein, we have performed a comparison of cellular response to each of general electrical stimulation and biomimetic electrical stimulation (BES) and demonstrated the synergy effects of electrical stimulation and ECM-mimetic nanopatterns. BES has provided the most remarkable proliferation among different types of electrical stimulation and upregulated the behavior of cells through synergy effects with ECM-mimetic nanopatterns. Thus, it is believed that using the synergy effects of BES and ECM-like nanopatterns has broad applications in the biomedical field, such as cell culture with electrical stimulation, induction of cell growth, tissue repair, etc. © 2020
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Engineering > School of Electrical Engineering > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.