Development of a neural interface for high-definition, long-term recording in rodents and nonhuman primates
- Authors
- Chiang C.-H.; Won S.M.; Orsborn A.L.; Yu K.J.; Trumpis M.; Bent B.; Wang C.; Xue Y.; Min S.; Woods V.; Yu C.; Kim B.H.; Kim S.B.; Huq R.; Li J.; Seo K.J.; Vitale F.; Richardson A.; Fang H.; Huang Y.; Shepard K.; Pesaran B.; Rogers J.A.; Viventi J.
- Issue Date
- Apr-2020
- Publisher
- NLM (Medline)
- Citation
- Science translational medicine, v.12, no.538
- Journal Title
- Science translational medicine
- Volume
- 12
- Number
- 538
- URI
- http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/38748
- DOI
- 10.1126/scitranslmed.aay4682
- ISSN
- 1946-6242
- Abstract
- Long-lasting, high-resolution neural interfaces that are ultrathin and flexible are essential for precise brain mapping and high-performance neuroprosthetic systems. Scaling to sample thousands of sites across large brain regions requires integrating powered electronics to multiplex many electrodes to a few external wires. However, existing multiplexed electrode arrays rely on encapsulation strategies that have limited implant lifetimes. Here, we developed a flexible, multiplexed electrode array, called Neural Matrix, that provides stable in vivo neural recordings in rodents and nonhuman primates. Neural Matrix lasts over a year and samples a centimeter-scale brain region using over a thousand channels. The long-lasting encapsulation (projected to last at least 6 years), scalable device design, and iterative in vivo optimization described here are essential components to overcoming current hurdles facing next-generation neural technologies. Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
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Collections - College of Engineering > ETC > 1. Journal Articles
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