Impact of the Dynamic Change of Metabolic Health Status on the Incident Type 2 Diabetes: A Nationwide Population-Based Cohort Study
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Jung A. | - |
dc.contributor.author | Kim, Da Hye | - |
dc.contributor.author | Kim, Seon Mee | - |
dc.contributor.author | Park, Yong Gyu | - |
dc.contributor.author | Kim, Nan Hee | - |
dc.contributor.author | Baik, Sei Hyun | - |
dc.contributor.author | Choi, Kyung Mook | - |
dc.contributor.author | Han, Kyungdo | - |
dc.contributor.author | Yoo, Hye Jin | - |
dc.date.available | 2020-09-14T08:06:50Z | - |
dc.date.created | 2020-06-17 | - |
dc.date.issued | 2019-12 | - |
dc.identifier.issn | 2093-596X | - |
dc.identifier.uri | http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/38820 | - |
dc.description.abstract | Background: Metabolically healthy obese (MHO) is regarded as a transient concept. We examined the effect of the dynamic change of metabolic health status on the incidence of type 2 diabetes mellitus (T2DM) both in obese and normal weight individuals. Methods: We analyzed 3,479,514 metabolically healthy subjects aged over 20 years from the Korean National Health Screening Program, who underwent health examination between 2009 and 2010, with a follow-up after 4 years. The relative risk for T2DM incidence until the December 2017 was compared among the four groups: stable metabolically healthy normal weight (MHNW), unstable MHNW, stable MHO, and unstable MHO. Results: During the 4 years, 11.1% of subjects in the MHNW group, and 31.5% in the MHO group converted to a metabolically unhealthy phenotype. In the multivariate adjusted model, the unstable MHO group showed the highest risk of T2DM (hazard ratio [HR], 4.67; 95% confidence interval [CI], 4.58 to 4.77). The unstable MHNW group had a higher risk of T2DM than stable MHO group ([HR, 3.23; 95% CI, 3.16 to 3.30] vs. [HR, 1.81; 95% CI, 1.76 to 1.85]). The stable MHO group showed a higher risk of T2DM than the stable MHNW group. The influence of the transition into a metabolically unhealthy phenotype on T2DM incidence was greater in subjects with aged <65 years, women, and those with weight gain. Conclusion: Metabolically healthy phenotype was transient both in normal weight and obese individuals. Maintaining metabolic health was critical for the prevention of T2DM, irrespective of their baseline body mass index. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN ENDOCRINE SOC | - |
dc.relation.isPartOf | ENDOCRINOLOGY AND METABOLISM | - |
dc.title | Impact of the Dynamic Change of Metabolic Health Status on the Incident Type 2 Diabetes: A Nationwide Population-Based Cohort Study | - |
dc.type | Article | - |
dc.identifier.doi | 10.3803/EnM.2019.34.4.406 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | ENDOCRINOLOGY AND METABOLISM, v.34, no.4, pp.406 - 414 | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000504856900010 | - |
dc.identifier.scopusid | 2-s2.0-85078416938 | - |
dc.citation.endPage | 414 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 406 | - |
dc.citation.title | ENDOCRINOLOGY AND METABOLISM | - |
dc.citation.volume | 34 | - |
dc.contributor.affiliatedAuthor | Han, Kyungdo | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.subject.keywordAuthor | Obesity | - |
dc.subject.keywordAuthor | Metabolic syndrome | - |
dc.subject.keywordAuthor | Diabetes mellitus, type 2 | - |
dc.subject.keywordPlus | UNHEALTHY NORMAL-WEIGHT | - |
dc.subject.keywordPlus | OBESITY | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | INDIVIDUALS | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | MELLITUS | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
Soongsil University Library 369 Sangdo-Ro, Dongjak-Gu, Seoul, Korea (06978)02-820-0733
COPYRIGHT ⓒ SOONGSIL UNIVERSITY, ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.