Risk of cancer in pre-dialysis chronic kidney disease: A nationwide population-based study with a matched control group
DC Field | Value | Language |
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dc.contributor.author | Park S. | - |
dc.contributor.author | Lee S. | - |
dc.contributor.author | Kim Y. | - |
dc.contributor.author | Lee Y. | - |
dc.contributor.author | Kang M.W. | - |
dc.contributor.author | Han K. | - |
dc.contributor.author | Han S.S. | - |
dc.contributor.author | Lee H. | - |
dc.contributor.author | Lee J.P. | - |
dc.contributor.author | Joo K.W. | - |
dc.contributor.author | Lim C.S. | - |
dc.contributor.author | Kim Y.S. | - |
dc.contributor.author | Kim D.K. | - |
dc.date.available | 2020-09-14T08:12:19Z | - |
dc.date.created | 2020-06-18 | - |
dc.date.issued | 2019-03 | - |
dc.identifier.issn | 2211-9132 | - |
dc.identifier.uri | http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/39062 | - |
dc.description.abstract | Background: Cancer risk and epidemiology in pre-dialysis chronic kidney disease (CKD) warrant further investigation in a large-scale cohort. Methods: We performed a nationwide population-based study using the national health insurance database of Korea. We screened records from 18,936,885 individuals who received a national health examination ≥ 2 times from 2009 to 2016. Pre-dialysis CKD was identified based on serum creatinine and dipstick albuminuria results. Individuals with preexisting cancer history, renal replacement therapy, or transient CKD were excluded. A control group without evidence of kidney function impairment and matched for age, sex, low-income status, and smoking history was included. Risk of cancers, as identified in the claims database, was investigated using a multivariable Cox regression model including matched variables and other unmatched clinical characteristics as covariates. Results: A total of 471,758 people with pre-dialysis CKD and the same number of matched controls were included. Urinary (adjusted hazard ratio [HR], 1.97; 95% confidence interval [95% CI], 1.82-2.13) and hematopoietic (adjusted HR, 1.53; 95% CI, 1.38-1.68) malignancy risk was increased in pre-dialysis CKD and all CKD stages. However, the risk of digestive cancer was lower in the pre-dialysis CKD group (adjusted HR, 0.89; 95% CI, 0.87-0.92). The risk of digestive, respiratory, thyroid, and prostate malignancy demonstrated a non-linear association with CKD stage, with stage 1 or stage 4/5 CKD without dialysis demonstrating relatively lower risk. Conclusion: Cancer risk varied in pre-dialysis CKD compared to controls, and the association between cancer risk and CKD stage varied depending on the cancer type. © 2019 by The Korean Society of Nephrology. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | The Korean Society of Nephrology | - |
dc.relation.isPartOf | Kidney Research and Clinical Practice | - |
dc.title | Risk of cancer in pre-dialysis chronic kidney disease: A nationwide population-based study with a matched control group | - |
dc.type | Article | - |
dc.identifier.doi | 10.23876/j.krcp.18.0131 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | Kidney Research and Clinical Practice, v.38, no.1, pp.60 - 70 | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000462002500009 | - |
dc.identifier.scopusid | 2-s2.0-85067314612 | - |
dc.citation.endPage | 70 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 60 | - |
dc.citation.title | Kidney Research and Clinical Practice | - |
dc.citation.volume | 38 | - |
dc.contributor.affiliatedAuthor | Han K. | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.subject.keywordAuthor | Cancer | - |
dc.subject.keywordAuthor | Chronic kidney disease | - |
dc.subject.keywordAuthor | Comorbidity | - |
dc.subject.keywordAuthor | Epidemiology | - |
dc.subject.keywordAuthor | Neoplasms | - |
dc.subject.keywordPlus | creatinine | - |
dc.subject.keywordPlus | adult | - |
dc.subject.keywordPlus | age | - |
dc.subject.keywordPlus | albuminuria | - |
dc.subject.keywordPlus | Article | - |
dc.subject.keywordPlus | body mass | - |
dc.subject.keywordPlus | cancer incidence | - |
dc.subject.keywordPlus | cancer risk | - |
dc.subject.keywordPlus | chronic kidney failure | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | diabetes mellitus | - |
dc.subject.keywordPlus | digestive system cancer | - |
dc.subject.keywordPlus | estimated glomerular filtration rate | - |
dc.subject.keywordPlus | female | - |
dc.subject.keywordPlus | gender | - |
dc.subject.keywordPlus | hemodialysis | - |
dc.subject.keywordPlus | human | - |
dc.subject.keywordPlus | hypertension | - |
dc.subject.keywordPlus | ICD-10 | - |
dc.subject.keywordPlus | low risk population | - |
dc.subject.keywordPlus | lowest income group | - |
dc.subject.keywordPlus | major clinical study | - |
dc.subject.keywordPlus | male | - |
dc.subject.keywordPlus | malignant neoplasm | - |
dc.subject.keywordPlus | middle aged | - |
dc.subject.keywordPlus | population based case control study | - |
dc.subject.keywordPlus | priority journal | - |
dc.subject.keywordPlus | renal replacement therapy | - |
dc.subject.keywordPlus | smoking | - |
dc.relation.journalResearchArea | Urology & Nephrology | - |
dc.relation.journalWebOfScienceCategory | Urology & Nephrology | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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